Cholecystokinin Excites Interneurons in Rat Basolateral Amygdala
Cholecystokinin Excites Interneurons in Rat Basolateral Amygdala
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DOI：
10.1152/jn.90769.2008
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发表时间：
2009-07-01
影响因子：
2.5
通讯作者：
Moore, Scott D.
中科院分区：
文献类型：
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作者：
Chung, Leeyup;Moore, Scott D.
Chung L，摩尔SD.胆固醇激肽兴奋大鼠基底外侧杏仁核中间神经元。J Neurophysiol 102：272-284，2009.首次发表于2009年4月22日; doi：10.1152/jn.90769.2008。杏仁核的形成与焦虑和恐惧等情绪状态的产生有关。许多调节杏仁核神经元活动的物质改变了焦虑。胆囊收缩素（CCK）是一种内源性神经肽，在动物和人类的行为研究中引起焦虑状态。使用脑切片制备，我们发现，CCK的应用程序增加抑制性突触传递测量在基底外侧杏仁核的投射神经元。为了确定增加抑制的来源，我们研究了CCK对该区域局部中间神经元的直接影响。CCK最强烈的去极化快速尖峰中间神经元。爆发性放电和规则放电的中间神经元也去极化，但程度较轻。然而，另一组不同的中间神经元不受CCK的影响。这些作用是由CCK B受体亚型介导的。CCK的兴奋作用似乎是由非选择性阳离子和K+电流介导的。
Chung L, Moore SD. Cholecystokinin excites interneurons in rat basolateral amygdala. J Neurophysiol 102: 272-284, 2009. First published April 22, 2009; doi:10.1152/jn.90769.2008. The amygdala formation is implicated in generation of emotional states such as anxiety and fear. Many substances that modulate neuronal activity in the amygdala alter anxiety. Cholecystokinin (CCK) is an endogenous neuropeptide that induces anxiety states in behavioral studies in both animals and humans. Using a brain slice preparation, we found that application of CCK increases inhibitory synaptic transmission measured in projection neurons of the basolateral amygdala. To determine the source of the increased inhibition we examined the direct effect of CCK on local interneurons in this region. CCK most strongly depolarized fast-spiking interneurons. Burst-firing and regular-firing interneurons were also depolarized, although to a lesser degree. However, another distinct group of interneurons was unaffected by CCK. These effects were mediated by the CCK B receptor subtype. The excitatory effect of CCK appeared to be mediated by both a nonselective cation and a K+ current.