Normative data of cortical excitability measurements obtained by transcranial magnetic stimulation in healthy subjects
Normative data of cortical excitability measurements obtained by transcranial magnetic stimulation in healthy subjects
复制标题
DOI：
10.1016/j.neucli.2015.12.003
复制
发表时间：
2016-02-01
影响因子：
3
通讯作者：
de Andrade, Daniel Ciampi
中科院分区：
文献类型：
--
作者：
Cueva, Ana Sofia;Galhardoni, Ricardo;de Andrade, Daniel Ciampi
目标。 - 通过经颅磁刺激获得 CE 测量的规范数据，评估研究者间/研究者内的变异性以及性别、年龄和口服避孕药使用的影响。方法。 - 对根据年龄和性别匹配的 216 名健康志愿者样本进行了评估。使用传递双相脉冲的圆形经颅磁刺激线圈，在初级运动皮层的第一背侧骨间肌区域中测量双侧静止运动阈值、运动诱发电位（MEP）、皮质内抑制和促进。获得了 200 名参与者（男女比例为 1:1）的规范数据，参与者的比例在五个年龄组（18-30；31-40；41-50；51-60；> 60 岁）之间保持平衡。在 30 分钟间隔内进行的两次会议中，对 20 名健康志愿者进行了研究人员间/内部变异性的评估。还对 16 名健康女性志愿者组成的亚组进行了测量，她们使用口服避孕药并在月经期间进行。结果。 -年龄对CE测量有二分效应，为<50岁和>50岁的受试者提供显着不同的规范数据，在老年个体中具有较小的MEP和皮质内抑制。性别之间或左右半球之间没有差异。此外，与周期的月经期相比，使用避孕治疗的 CE 参数没有显着差异。研究者间/研究者内的可靠性评估显示出一些可能不具有临床意义的变异性。结论。 - 年龄对 CE 有非线性影响。性别、半球或口服避孕药的使用之间没有显着差异。静息运动阈值和运动诱发电位具有良好的研究者间/研究者内相关性，而皮质内抑制和促进的相关性较低，但可靠性可接受。 2016 爱思唯尔马森公司。版权所有。
Objectives. - To obtain normative data for CE measurements by transcranial magnetic stimulation, to assess inter- /intra-investigator variability and the influence of sex, age and oral contraception use.Methods. - A sample of 216 healthy volunteers matched according to age and gender was evaluated. Bilateral rest motor thresholds, motor evoked potentials (MEP), intracortical inhibition and facilitation were measured in the first dorsal interosseous muscle area representation of the primary motor cortex with a circular transcranial magnetic stimulation coil delivering biphasic pulses. Normative data were obtained for 200 participants (in a 1:1 male:female ratio) in a balanced proportion between five age groups (18-30; 31-40; 41-50; 51-60; > 60 years). Inter/intra-investigator variability was assessed in 20 healthy volunteers in two sessions performed within a 30-minute interval. Measurements were also performed in a subgroup of 16 healthy female volunteers, using oral contraception and during the menstrual phase.Results. - Age had a dichotomous effect on CE measurements, providing significantly different normative data for subjects < 50 and > 50 years old, with smaller MEP's and intracortical inhibition in older individuals. There were no differences between genders or between left and right hemispheres. Also, CE parameters did not significantly differ with use of contraceptive treatment compared to the menstrual phase of the cycle. The inter-/intra-investigator reliability assessment showed some variability that may not be clinically significant.Conclusions. - Age had a non-linear effect on CE. There were non-significant differences between genders, hemispheres or with use of oral contraceptives. There was good inter- /intra-investigator correlation for rest motor thresholds and motor evoked potentials while intracortical inhibition and facilitation had low correlations but acceptable reliability. 2016 Elsevier Masson SAS. All rights reserved.