Activation of pyrazinamide and nicotinamide in acidic environments in vitro.
Activation of pyrazinamide and nicotinamide in acidic environments in vitro.
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DOI：
10.1164/art.1954.70.4.748
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发表时间：
1954-10
期刊：
影响因子：
--
通讯作者：
W. Mcdermott;R. Tompsett
中科院分区：
文献类型：
--
作者：
W. Mcdermott;R. Tompsett
注释749没有详细到完全排除这类可能性的程度，它们没有为吡嗪酰胺通过转化为具有容易证明的体外活性的物质而发挥其作用的观点提供支持。此外，在小鼠实验中，发现吡嗪酰胺处理的动物的组织在体外测试时对结核杆菌没有抑制作用。
NOTES 749 not so detailed as to exclude completely all possibilities of this sort, they provided no support for the notion that pyrazinamide exerted its effects by being transformed into a substance with readily demonstrable in vitro activity. Moreover, in experiments in mice, it was found that the tissues of pyrazinamide-treated animals had no inhibitory effect on tubercle bacilli when tested in vitro.