Loneliness, social network size, and immune response to influenza vaccination in college freshmen
Loneliness, social network size, and immune response to influenza vaccination in college freshmen
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DOI：
10.1037/0278-6133.24.3.297
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发表时间：
2005-05-01
影响因子：
4.2
通讯作者：
Treanor, JJ
中科院分区：
文献类型：
--
作者：
Pressman, SD;Cohen, S;Treanor, JJ
对83名健康大学新生进行了流感疫苗免疫后的抗体应答调查。整个学期孤独感水平的提高和小型社交网络与对疫苗I组分较差的抗体反应独立相关。那些同时具有高度孤独感和较小社交网络的人的抗体反应最低。孤独还与更大的心理压力和负面情绪，较少的积极情绪，较差的睡眠效率和质量，以及循环皮质醇水平的升高有关。然而，只有应激数据与孤独感-抗体反应关系的中介作用一致。这些变量都不与社会网络规模相关，因此也不是网络规模和免疫应答之间关系的潜在中介。
Antibody response to the influenza immunization was investigated in 83 1st-semester healthy university freshmen. Elevated levels of loneliness throughout the semester and small social networks were independently associated with poorer antibody response to I component of the vaccine. Those with both high levels of loneliness and a small social network had the lowest antibody response. Loneliness was also associated with greater psychological stress and negative affect, less positive affect, poorer sleep efficiency and quality, and elevations in circulating levels of cortisol. However, only the stress data were consistent with mediation of the loneliness-antibody response relation. None of these variables were associated with social network size, and hence none were potential mediators of the relation between network size and immunization response.