Estradiol modulation of oxytocin binding in the ventromedial hypothalamic nucleus of male and female rats.
Estradiol modulation of oxytocin binding in the ventromedial hypothalamic nucleus of male and female rats.
复制标题
雌二醇对雄性和雌性大鼠下丘脑腹内侧核中催产素结合的调节。
DOI：
10.1159/000125221
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发表时间：
1989
影响因子：
4.1
通讯作者：
McEwen,BS
中科院分区：
文献类型：
--
作者：
Coirini,H;Johnson,AE;McEwen,BS
有研究表明，雌二醇和催产素（OT）可能作为神经内分泌成分在性行为调节中相互作用。在本研究中，评价了苯甲酸雌二醇（EB）处理（50 µg/kg体重/2天）对成年和21日龄性腺切除雄性和雌性大鼠脑中[3 H]-OT结合的影响。通过下丘脑腹内侧核（VMN）的冠状面在三个不同的截面进行了分析。EB引发引起雄性和雌性大鼠VMN中[3 H]-OT结合增加。更大的结合位点密度和显着的EB效应被发现在最尾侧平面的VMN的腹外侧部分是很好地定义在这两个年龄。OT结合在中央杏仁核不受这种治疗，但较高的结合水平被发现在最尾部部分，无论激素状态或性别。在基础或EB处理的动物的VMN中未检测到OT结合的性别差异。这些结果表明，在雌性大鼠中激活雌性性行为而在雄性大鼠中不激活雌性性行为的EB剂量能够在两种性别动物的VMN中诱导相似水平的OT结合。
It has been suggested that estradiol and oxytocin (OT) may interact as neuroendocrine components in the regulation of sexual behavior. In the present study the effect of estradiol benzoate (EB) treatment (50 µg/kg body weight/2 days) on [3H]-OT binding was evaluated in adult and 21-day-old gonadectomized male and female rat brains. Coronal sections through the ventromedial nucleus of the hypothalamus (VMN) were analyzed in three different section planes. EB priming induced an increase in [3H]-OT binding in the VMN of both male and female rats. Greater binding site density and significant EB effects were found in the most caudal plane where the ventrolateral portion of the VMN is well defined at both ages. OT binding in the central amygdaloid nucleus was not affected by this treatment but higher binding levels were found in the most caudal sections irrespective of hormonal status or sex. No sex differences were detected in OTbinding in the VMN of basal or EB-treated animals. These results suggest that a dose of EB which activates female sexual behavior in female but not in male rats is able to induce similar levels of OT binding in the VMN of animals of both sexes.