INTERLEUKIN-3 STIMULATES PHOSPHATIDYLCHOLINE TURNOVER IN A MAST MEGAKARYOCYTE CELL-LINE
INTERLEUKIN-3 STIMULATES PHOSPHATIDYLCHOLINE TURNOVER IN A MAST MEGAKARYOCYTE CELL-LINE
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DOI：
10.1016/0006-291x(89)91530-1
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发表时间：
1989-10-31
影响因子：
3.1
通讯作者：
PELECH, SL
中科院分区：
文献类型：
--
作者：
DURONIO, V;NIP, L;PELECH, SL
The hemopoietic growth factor, interleukin 3, has been shown to activate protein kinase C without causing hydrolysis of inositol phospholipids. The potential involvement of phosphatidylcholine hydrolysis as an alternative source of diacylglycerol was investigated in an interleukin 3-dependent murine mast/megakaryocyte cell line, R6-XE.4. Treatment of these cells with interleukin 3 rapidly stimulated both the release of water-soluble choline metabolites and the resynthesis of phosphatidylcholine. Therefore, a phosphatidylcholine cycle may operate as part of the signal transduction pathway in cells responding to interleukin 3.
