Maintenance of distinct melanocyte populations in the interfollicular epidermis.
Maintenance of distinct melanocyte populations in the interfollicular epidermis.
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DOI：
10.1111/pcmr.12375
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发表时间：
2015-07
影响因子：
4.3
通讯作者：
Headon DJ
中科院分区：
文献类型：
--
作者：
Glover JD;Knolle S;Wells KL;Liu D;Jackson IJ;Mort RL;Headon DJ
毛囊和汗腺被认为是黑素细胞干细胞(MSCs)的储存库。与已分化的黑素细胞不同，未分化的MSCs不会产生黑色素。它们是毛囊分化的黑素细胞的来源，在受伤、暴露于紫外线照射或白癜风缓解时，它们有助于毛囊间表皮的形成，白癜风的重新着色通常会从毛囊向外扩散。目前尚不清楚这些观察是否反映了正常的黑素细胞更新的稳态机制，或者未受干扰的毛囊间表皮是否能够维持独立于皮肤附属物的黑素细胞数量。在这里，我们展示了缺乏附属物的小鼠尾部皮肤在成年后确实保持了稳定的黑素细胞数量，包括低频率的无色素性黑素细胞。此外，我们发现在出生后的皮肤中存在活跃的周期分化的黑素细胞，这表明无色素性黑素细胞并不是唯一依赖于黑素细胞稳态的细胞。
Hair follicles and sweat glands are recognized as reservoirs of melanocyte stem cells (MSCs). Unlike differentiated melanocytes, undifferentiated MSCs do not produce melanin. They serve as a source of differentiated melanocytes for the hair follicle and contribute to the interfollicular epidermis upon wounding, exposure to ultraviolet irradiation or in remission from vitiligo, where repigmentation often spreads outwards from the hair follicles. It is unknown whether these observations reflect the normal homoeostatic mechanism of melanocyte renewal or whether unperturbed interfollicular epidermis can maintain a melanocyte population that is independent of the skin's appendages. Here, we show that mouse tail skin lacking appendages does maintain a stable melanocyte number, including a low frequency of amelanotic melanocytes, into adult life. Furthermore, we show that actively cycling differentiated melanocytes are present in postnatal skin, indicating that amelanotic melanocytes are not uniquely relied on for melanocyte homoeostasis.