Sleep Duration and Cardiometabolic Risk Among Chinese School-aged Children: Do Adipokines Play a Mediating Role?
Sleep Duration and Cardiometabolic Risk Among Chinese School-aged Children: Do Adipokines Play a Mediating Role?
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DOI：
10.1093/sleep/zsx042
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发表时间：
2017-05-01
期刊：
影响因子：
5.6
通讯作者：
Li, Ming
中科院分区：
文献类型：
--
作者：
Li, Lujiao;Fu, Junling;Li, Ming
研究目的：评估中国学龄儿童睡眠时间与心脏代谢危险因素之间的关系，并探讨脂肪因子可能在其中的中介作用。方法：收集北京市儿童与青少年代谢综合征研究中心3166例儿童的睡眠时间。评估葡萄糖稳态和其他心脏代谢危险因素。测定血清脂肪因子包括瘦素、总脂联素、高分子量脂联素、抵抗素、成纤维细胞生长因子21 （FGF21）、视黄醇结合蛋白4 （RBP4）。结果：在6- 12岁的儿童中，在调整了包括青春期在内的协变量后，睡眠时间短与体重指数（BMI）、腰围、空腹血糖、胰岛素和胰岛素抵抗的稳态模型评估（均p < 0.0001）、甘油三酯升高和高密度脂蛋白胆固醇降低（p < 0.05）、瘦素升高（p < 0.0001）、FGF21升高（p < 0.05）和hw -脂联素降低（p < 0.05）相关
Study Objectives: To assess the associations between sleep duration and cardiometabolic risk factors in Chinese school-aged children and to explore the possible mediating role of adipokines.Methods: Sleep duration was collected in 3166 children from the Beijing Child and Adolescent Metabolic Syndrome study. Glucose homeostasis and other cardiometabolic risk factors were assessed. Serum adipokines including leptin, total and high-molecular-weight (HMW) adiponectin, resistin, fibroblast growth factor 21 (FGF21), and retinol binding protein 4 (RBP4) were determined.Results: Among the 6-to 12-year-old children, after adjusting for covariates including puberty, short sleep duration was associated with increased body mass index (BMI), waist circumference, fasting glucose, insulin and homeostasis model assessment of insulin resistance (all p < .0001), higher triglyceride and lower high-density lipoprotein cholesterol (p < .05), along with increased leptin (p < .0001), FGF21 (p < .05) and decreased HMW-adiponectin (p