Lowering the tone: Mechanisms of immunodominance among epitopes with low affinity for MHC
Lowering the tone: Mechanisms of immunodominance among epitopes with low affinity for MHC
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DOI：
10.1016/0167-5699(96)80584-6
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发表时间：
1996-02-01
期刊：
影响因子：
--
通讯作者：
Wraith, DC
中科院分区：
文献类型：
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作者：
Fairchild, PJ;Wraith, DC
过去对T细胞表位之间免疫优势的研究集中在对其限制性元件具有高亲和力的肽上，假设低亲和力的表位在免疫学上不相关。在这里，保罗费尔柴尔德和大卫幽灵挑战这一假设，审查证据表明，这些肽可能有助于T细胞库的选择和自身免疫性疾病，并建议方法的基础上利用这些肽的免疫治疗。
Past studies of immunodominance among T-cell epitopes have focused on peptides with high affinity for their restriction element, assuming epitopes of low affinity to be immunologically irrelevant. Here, Paul Fairchild and David Wraith challenge this assumption by reviewing evidence that such peptides may contribute to T-cell repertoire selection and autoimmune disease, and suggest approaches to immunotherapy based on exploitation of these peptides.