Prognostic value of E-cadherin immunoexpression in patients with primary ovarian carcinomas
Prognostic value of E-cadherin immunoexpression in patients with primary ovarian carcinomas
复制标题
DOI：
10.1093/annonc/mdh387
复制
发表时间：
2004-10-01
影响因子：
50.5
通讯作者：
Lopes, CS
中科院分区：
文献类型：
--
作者：
Faleiro-Rodrigues, C;Macedo-Pinto, I;Lopes, CS
目的：分析E-钙粘蛋白在卵巢癌组织中的表达，探讨其与卵巢癌临床病理特征、总生存率和无复发生存率的关系。方法：采用免疫组织化学方法检测104例卵巢癌石蜡包埋标本中E-钙粘蛋白的表达。研究的临床病理因素包括年龄、FIGO分期、组织学类型、肿瘤分化程度、卵巢包膜的出现情况、腹膜植入物、细胞减灭术后残留肿瘤等。结果：104例乳腺癌中，E-钙粘素免疫表达阴性者7例(7%)，阳性者97例(93%)。E-钙粘附素分为阴性和阳性表达，与任何已建立的临床病理参数无关。然而，E-钙粘附素表达阴性与阳性表达相比，其总生存率显著低于E-钙粘附素表达(P=0.006)。在多因素分析中，E-钙粘附素阴性和肿瘤减灭术后残留肿瘤是影响患者生存的独立预后因素(P=0.014和P=0.034)。结论：卵巢癌直接细胞减灭术后肿瘤残留和E-钙粘附素表达阴性可能是卵巢癌患者预后不良的有用指标。E-钙粘素免疫反应性的评估可能是卵巢癌的一个有用的预后指标，与已有的预后因素相辅相成。
Purpose: To analyse the negative versus positive immunoexpression of E-cadherin in patients with primary ovarian carcinomas, and determine its significance in relation to clinicopathological features, overall and recurrence-free survival (RFS).Patients and methods: The protein expression of E-cadherin was immunohistochemically evaluated in formalin-fixed, paraffin-embedded samples in 104 patients with primary ovarian carcinomas. The clinicopathological factors studied were age, FIGO staging, histological type, tumour differentiation, the appearance of the ovarian capsule, peritoneal implants and residual tumour after cytoreductive surgery. Overall survival and RFS were evaluated using the Kaplan-Meier method, and multivariate analysis was completed using the Cox regression model.Results: Of the 104 carcinomas, negative E-cadherin immunoexpression was observed in seven (7%) cases, and positive immunoexpression in 97 (93%). E-cadherin categorised into negative versus positive expression did not associate with any of the established clinicopathological parameters. However, negative E-cadherin expression significantly predicted a poorer overall survival when compared with positive expression (P=0.006). In the multivariate analyses, negative E-cadherin and the presence of residual tumour after cytoreductive surgery were independent prognostic factors for survival (P=0.014 and P=0.034, respectively).Conclusions: The presence of residual tumour after primary cytoreductive surgery and negative E-cadherin expression seem to be useful markers in patients with ovarian carcinomas likely to have an unfavourable clinical outcome. The assessment of E-cadherin immunoreactivity may be a useful prognostic indicator in ovarian cancer, complementary to established prognostic factors.