Are transcutaneous oxygen and carbon dioxide determinations of value in pulmonary arterial hypertension?
Are transcutaneous oxygen and carbon dioxide determinations of value in pulmonary arterial hypertension?
复制标题
经皮氧和二氧化碳测定对肺动脉高压有价值吗？
DOI：
10.1111/micc.12191
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Dweik,RaedA
中科院分区：
文献类型：
--
作者：
Tonelli,AdrianoR;Alkukhun,Laith;Cikach,Frank;Ahmed,Mostafa;Dweik,RaedA
背景我们假设 O2 和 CO2（TcPO2 和 TcPCO2）的经皮气体测定与 PAH 的严重程度相关。方法在这项横断面研究中，我们纳入了连续的 PAH 患者（第 1 组 PH；n= 34）。将经皮气体测定结果与年龄和性别匹配的健康对照 (n=14)、非 1 类 PH (n=19) 或超声心动图估计 RVSP 高但无 PH 血流动力学证据的患者 (n=12) 进行比较。结果在 PAH 患者中，TcPO2 和 TcPCO2 与 PaO2 显着相关（R= 0.44，p= 0.03）和PaCO2(R= 0.77,p< 0.001) 分别。 PAH 患者的 TcPO2/FiO2（平均差：−65.0 [95% CI：−121.3，−8.7]）和 TcPCO2（平均差：−7.4 [95% CI：−11.6，−3.1]）显着低于健康对照。 TcPCO2 可用于区分 PAH 患者和其他个体（AUC：0.74 [95% CI：0.62，0.83]）。 TcPO2/FiO2 比值与平均 PAP、TPG、PVR、CI、SVI、DLCO、六分钟步行距离和 CAMPHOR 问卷的组成部分显着相关。结论 PAH 患者的经皮 CO2 压力较低。经皮 O2 压力与 O2 吸入分数之比与 PAH 患者的疾病严重程度呈负相关。
BackgroundWe hypothesized that transcutaneous gas determinations of O2and CO2(TcPO2and TcPCO2) are associated with the severity of PAH.MethodsIn this cross‐sectional study, we included consecutive patients with PAH (group 1 PH;n= 34). Transcutaneous gas determinations were compared to those of age‐ and gender‐matched healthy controls (n= 14), nongroup 1 PH (n= 19) or patients with high estimated RVSP on echocardiography but without hemodynamic evidence of PH (n= 12).ResultsIn patients with PAH, TcPO2, and TcPCO2were significantly associated with PaO2(R= 0.44,p= 0.03) and PaCO2(R= 0.77,p< 0.001), respectively. TcPO2/FiO2(mean difference: −65.0 [95% CI: −121.3, −8.7]) and TcPCO2(mean difference: −7.4 [95% CI: −11.6, −3.1]) were significantly lower in patients with PAH than healthy controls. TcPCO2was useful in discriminating PAH patients from other individuals (AUC: 0.74 [95% CI: 0.62, 0.83]). TcPO2/FiO2ratio was significantly associated with mean PAP, TPG, PVR, CI, SVI, DLCO, six‐minute walk distance and components of the CAMPHOR questionnaire.ConclusionsTranscutaneous pressure of CO2was lower in patients with PAH. Transcutaneous pressure of O2over inspired fraction of O2ratio was inversely associated with severity of disease in patients with PAH.
影响因子：
4.3
作者：
H. Sambrook
通讯作者：
H. Sambrook