Nickel-Catalyzed Reductive Thiolation of Unactivated Alkyl Bromides and Arenesulfonyl Cyanides
Nickel-Catalyzed Reductive Thiolation of Unactivated Alkyl Bromides and Arenesulfonyl Cyanides
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镍催化未活化的烷基溴和芳磺酰氰化物的还原硫醇化
DOI：
10.1021/acs.joc.1c00903
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发表时间：
2021
影响因子：
3.6
通讯作者：
Wang Shun-Yi
中科院分区：
文献类型：
--
作者：
Wang Fei;Rao Weidong;Wang Shun-Yi
研究了Ni（acac）2催化未活化的溴代烷烃与芳烃磺酰氰在还原条件下交叉亲电偶联生成不对称硫醚的反应。这种用于硫化物合成的方法是实用的，依赖于可用的未官能化的材料，如烷基（假）卤化物，并且是可扩展的。这种催化策略为在温和条件下制备具有良好官能团耐受性的不对称烷基芳基硫醚提供了一种补充方法。
The cross-electrophile coupling between unactivated alkyl bromides with arenesulfonyl cyanides catalyzed by Ni(acac)2under reductive conditions to form unsymmetrical sulfides is developed. This approach for sulfide synthesis is practical, relies on available, unfunctionalized materials such as alkyl (pseudo)halides, and is scalable. This catalytic strategy provides a complementary method for the preparation of unsymmetrical alkyl–aryl sulfides under mild conditions with good functional group tolerance.