Harmonic analysis of perfusion pumps
Harmonic analysis of perfusion pumps
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DOI：
10.1115/1.1632524
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发表时间：
2003-12-01
影响因子：
1.7
通讯作者：
Townsley, MI
中科院分区：
文献类型：
--
作者：
Dougherty, FC;Donovan, FM;Townsley, MI
关于在离体灌注过程中使用非脉动泵与脉动泵维持正常器官功能的争议已持续多年，但由于缺乏脉动性的一致数学定义，解决方案受到限制。我们假设波形频率和振幅以及潜在的平均扩张压力都是控制血管功能的关键参数。使用离散傅立叶分析，我们的数据证明了体内肺动脉压波形的复杂性和常用灌注泵模拟体内动力学的失败。此外，我们的数据表明，关键谐波特征是灌注泵固有的，对于流量和压力波形是相似的，并且是下游灌注回路或灌注液粘度的不变的B特性。
The controversy over,the use of nonpulsatile versus pulsatile pumps for maintenance of normal organ function during ex vivo perfusion has continued for many years, but resolution has been limited by lack of a congruent mathematical definition of pulsatility. We hypothesized that the waveform frequency and amplitude, as well as the underlying mean distending pressure are all key parameters controlling vascular function. Using discrete Fourier Analysis, our data demonstrate the complexity of the pulmonary arterial pressure waveform in vivo and the failure of commonly available perfusion pumps to mimic in vivo dynamics. In addition, our data show that the key harmonic signatures are intrinsic to the perfusion pumps, are similar for flow and pressure waveforms, and are unchanged b characteristics of the downstream perfusion circuit or perfusate viscosity.