Resistance Training Impact on Mobility, Muscle Strength and Lean Mass in Pancreatic Cancer Cachexia: A Randomized Controlled Trial
Resistance Training Impact on Mobility, Muscle Strength and Lean Mass in Pancreatic Cancer Cachexia: A Randomized Controlled Trial
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DOI：
10.1177/0269215520941912
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发表时间：
2020-07-13
影响因子：
3
通讯作者：
Salama, Amr B.
中科院分区：
文献类型：
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作者：
Kamel, FatmaAlzahraa H.;Basha, Maged A.;Salama, Amr B.
目的：探讨为期3个月的阻力训练对胰腺癌恶病质患者活动能力、肌力和瘦体质量的影响。设计：随机对照试验。单位：埃及开罗，埃尔萨赫勒教学医院，理疗学院门诊部。对象：胰腺癌所致恶病质患者。干预：将受试者随机分为抵抗训练组和对照组各20例。主要测量：在基线、手术切除后3个月和干预后12周测量结果，包括活动度、肌力和瘦体质量。结果：平均年龄51.9(5.03)岁，体重指数21.1(1.13)kg/m(2)，男性占65%。与对照组相比，抗阻训练组在活动能力方面有明显改善：400m步行成绩(分别为270.3~256.9秒比266.4~264.2秒)和椅子起立成绩(分别为13.82~12.53秒比13.77~13.46秒)。同样，阻力训练组的肌力也明显高于对照组，膝关节伸肌(P=0.004)、肘屈肌(P=0.001)和伸肘肌的峰值扭矩增加，上肢瘦质量(分别为6.28~6.46kgvs6.31~6.23 kg)和小腿(分别为16.31~16.58kgvs16.4~16.31 kg)有所改善。结论：为期三个月的阻力训练改善了胰腺癌恶病质患者的活动能力。肌肉力量和瘦体重也有所改善。
Objective: To determine the efficacy of a three-month resistance training programme on the mobility, muscle strength and lean body mass of patients with pancreatic cancer-induced cachexia. Design: Randomized controlled trial. Setting: Elsahel Teaching Hospital, outpatient clinic of the Faculty of Physical Therapy, Cairo, Egypt. Participants: Patients with pancreatic cancer-induced cachexia. Interventions: Participants were randomized to the resistance training group (n = 20) and control group (n = 20). Main measures: Outcomes including mobility, muscle strength and lean body mass were measured at baseline, three months after surgical resection and 12 weeks after intervention. Results: The mean (SD) age was 51.9 (5.03) years and body mass index was 21.1 (1.13) kg/m(2); 65% of patients were male. Compared to the control group, the resistance training group showed significant improvement in mobility: 400-m walk performance (270.3-256.9 seconds vs 266.4-264.2 seconds, respectively) and chair rise (13.82-12.53 seconds vs 13.77-13.46 seconds, respectively). Similarly, muscle strength was also significantly improved in the resistance training group than in the control group; we observed increase in peak torque of knee extensors (P = 0.004), elbow flexors (P = 0.001) and elbow extensors, improvement in lean mass of the upper limb (6.28-6.46 kg vs 6.31-6.23 kg, respectively) and lower limb (16.31-16.58 kg vs 16.4-16.31 kg, respectively). Conclusion: A three-month resistance training improved the mobility of patients with pancreatic cancer-induced cachexia. Muscle strength and lean body mass also improved.