CD4/CD8-negative T cells with alpha beta antigen receptors.

CD4/CD8-negative T cells with alpha beta antigen receptors.
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具有 αβ 抗原受体的 CD4/CD8 阴性 T 细胞。

DOI:
10.1016/0952-7915(94)90124-4
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发表时间:
1994
影响因子:
7
通讯作者:
Crispe,IN
Crispe,IN
中科院分区:
医学2区
文献类型:
--
作者:
Crispe,IN

文献摘要

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相似文献

少量αβ T细胞既不表达CD 4也不表达CD 8。这些细胞可能是异质的。它们在解剖学分布中广泛,表达异常的T细胞库,基本上不受作用于CD 4+和CD 8 +T细胞的选择性过程的影响,并表现出细胞毒性和Th-2样功能。它们在正常免疫功能中的作用是完全模糊的,但它们在小鼠和人类自身免疫性疾病中是活跃的。
A minor population of αβ T cells expresses neither CD4 nor CD8. These cells are probably heterogeneous. They are widespread in anatomical distribution, express an abnormal T-cell repertoire largely unaffected by selective processes that act on CD4+and CD8+T cells, and exhibit both cytotoxic and Th-2-like functions. Their role in normal immune function is completely obscure, but they are active in murine and human autoimmune disease.