[Teratosis and damage of viscera induced by microcystin in SD rat fetuses].
[Teratosis and damage of viscera induced by microcystin in SD rat fetuses].
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发表时间：
2002-03
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通讯作者：
Zhanying Zhang;M. Lian;Y. Liu;G. Wei;Shun-zhang Yu;Suya Kang;Youchen Zhang;Chuanwei Chen
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作者：
Zhanying Zhang;M. Lian;Y. Liu;G. Wei;Shun-zhang Yu;Suya Kang;Youchen Zhang;Chuanwei Chen
目的研究微囊藻毒素LR （microcystin LR， MCLR）对妊娠SD大鼠及其胎儿的致畸性和创伤性作用。方法将60只妊娠SD大鼠分为4组，每组16只：3个实验组分别以4、16、62微克/kg的剂量腹腔注射MCLR，持续10 d，对照组注射生理盐水。20天后，怀孕的老鼠被杀死。检查胎儿的发育、畸形和脏器组织学。结果62和16微克/kg组胎儿均出现畸形，致畸率分别为11.70 /千（2/172）和6.76 /千（1/155）。62微克/公斤组出现肝点状出血、严重积水变性及肾小球和肾髓质发育不良。4微克/kg组胎儿肝脏出现轻度颗粒变性。结论MCLR可通过胎盘屏障对肾脏和肝脏造成损害，这可能是胎儿期肝癌微图高发的基础。
OBJECTIVE To study the teratogenicity and traumatic effect of microcystin LR (MCLR) on pregnant SD rats and their fetuses. METHODS Sixty pregnant SD rats were divided into four groups, 16 in each group: three experimental groups in which MCLR was injected into the abdominal cavity at the doses of 4 microgram/kg, 16 microgram/kg, and 62 microgram/kg respectively for 10 days, and control group injected with normal saline. Twenty days after, the pregnant rats were killed. The development, teratosis, and histology of viscera of the fetuses were examined. RESULTS Deformities were found in the fetuses of the 62 microgram/kg group and 16 microgram/kg group with the teratogenic rate of 11.70 per thousand (2/172) and 6.76 per thousand (1/155). Petechial hemorrhage and severe hydropic degeneration in liver and maldevelopment of glomeruli and renal medulla were found in 62 microgram/kg group. Mild granular degeneration was found in the liver of fetuses in 4 microgram/kg group. CONCLUSION MCLR passes through the placental barrier and causes damage in kidney and liver, which may be the basis of high incidence of liver cancer microgram in the fetus phase.