Lung epithelial healing: a modified seed and soil concept.
Lung epithelial healing: a modified seed and soil concept.
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DOI：
10.1513/pats.201201-008ms
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发表时间：
2012-05-01
期刊：
影响因子：
--
通讯作者：
Ghosh, Moumita
中科院分区：
文献类型：
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作者：
Reynolds, Susan D;Brechbuhl, Heather M;Ghosh, Moumita
呼吸道上皮愈合的定义是恢复健康或健全；治愈。我们的研究表明，两种类型的祖细胞参与了这一过程：组织特异性干细胞(TSC)和兼性基础祖细胞(FBP)。TSC将上皮恢复到其正常的结构和功能。因此，TSC可以再生上皮。相反，FBP来源的上皮以细胞增殖和发育不良区域为特征。由于FBP来源的上皮细胞偏离正常，我们称之为FBP介导的过程修复。我们的工作表明，TSC对来自其他上皮细胞的信号做出反应，包括FBP。这些信号指示TSC增殖或选择几条分化途径中的一条。我们在斯蒂芬·帕吉特的“种子和土壤”范式的背景下解读这些数据。其中，Padget解释说，肿瘤种子到特定部位土壤的转移是由肿瘤细胞的生长和分化要求决定的。通过将种子和土壤范式扩展到呼吸道上皮愈合，我们认为种子TSC的增殖和分化取决于它与其他类型的细胞，土壤的相互作用。基于这一概念，我们为发展针对慢性呼吸道疾病的基于细胞的疗法提供了一系列建议。
Airway epithelial healing is defined as restoration of health or soundness; to cure. Our research indicates that two types of progenitor cells participate in this process: the tissue-specific stem cell (TSC) and the facultative basal progenitor (FBP). The TSC restores the epithelium to its normal structure and function. Thus, the TSC regenerates the epithelium. In contrast, the FBP-derived epithelium is characterized by regions of cellular hyperplasia and hypoplasia. Since the FBP-derived epithelium deviates from normal, we term the FBP-mediated process repair. Our work indicates that the TSC responds to signals from other epithelial cells, including the FBP. These signals instruct the TSC to proliferate or to select one of several differentiation pathways. We interpret these data in the context of Stephen Padget's "seed and soil" paradigm. Therein, Padget explained that metastasis of a tumor, the seed, to a specific site, the soil, was determined by the growth and differentiation requirements of the tumor cell. By extending the seed and soil paradigm to airway epithelial healing, we suggest that proliferation and differentiation of the TSC, the seed, is determined by its interactions with other cell types, the soil. Based on this concept, we provide a set of suggestions for development of cell-based therapies that are directed toward chronic airways disease.