High dose rate prostate brachytherapy: an overview of the rationale, experience and emerging applications in the treatment of prostate cancer.
High dose rate prostate brachytherapy: an overview of the rationale, experience and emerging applications in the treatment of prostate cancer.
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DOI：
10.1259/bjr/15403217
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发表时间：
2012-11-01
期刊：
影响因子：
--
通讯作者：
Mangar, S A
中科院分区：
文献类型：
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作者：
Challapalli, A;Jones, E;Mangar, S A
用于高剂量率（HDR）前列腺近距离放射治疗的实时超声图像引导技术的进步使这种治疗方式处于放射治疗创新的最前沿。这篇综述文章将探讨HDR近距离放射治疗作为一种高度适形的前列腺剂量输送和安全剂量递增方法的基本原理，以及它相对于低剂量率和外射束放射治疗的特殊放射生物学优势。令人鼓舞的结果数据和有利的毒性特征将在未来的新兴应用中进行讨论，以及该程序将如何与立体定向放射外科一起使用。
The technological advances in real-time ultrasound image guidance for high dose rate (HDR) prostate brachytherapy places this treatment modality at the forefront of innovation in radiotherapy. This review article will explore the rationale for HDR brachytherapy as a highly conformal method of dose delivery and safe dose escalation to the prostate, in addition to the particular radiobiological advantages it has over low dose rate and external beam radiotherapy. The encouraging outcome data and favourable toxicity profile will be discussed before looking at emerging applications for the future and how this procedure will feature alongside stereotactic radiosurgery.