A study of cross‐tolerance to circulatory effects of organic nitrates
A study of cross‐tolerance to circulatory effects of organic nitrates
复制标题
有机硝酸盐循环效应交叉耐受性的研究
DOI：
10.1002/cpt196782256
复制
发表时间：
1967
影响因子：
6.7
通讯作者：
L. Lasagna
中科院分区：
文献类型：
--
作者：
J. Schelling;L. Lasagna
10名住院的志愿者受试者在四周内每天分次服用季戊四醇四硝酸酯（PETN）。在PETN治疗前和治疗期间，受试者接受0.3 mg PETN激发。舌下含服硝酸甘油（NTC）。当受试者接受PETN时，NTC后血压和心率的变化显著降低。在PETN给药期间，NTC和PETN相关头痛的报告也有所减少。由于长效硝酸盐可能通过耐受性的发展而携带其自身治疗失败的种子，因此建议对此类药物的动物研究通常包括旨在检测和测量对心血管和其他作用耐受性的发展的重复药理学试验。
Ten hospitalized volunteer subjects were given pentaerythrol tetra nitrate (PETN) daily in divided doses over a period of four weeks. Before and during PETN treatment, the subjects were challenged with 0.3 mg. sublingual nitroglycerin (NTC). The changes in blood pressure and heart rate after NTC were significantly decreased while subjects were receiving PETN. Reports of NTC‐ and PETN‐related headache also decreased during PETN administration. Since long‐acting nitrates may carry within them the seeds of their own therapeutic failure via the development of tolerance, it is suggested that animal studies on such agents routinely include repeated pharmacological testing designed to detect and measure the development of tolerance to cardiovascular and other effects.