Population pharmacokinetics of tacrolimus in children with nephrotic syndrome
Population pharmacokinetics of tacrolimus in children with nephrotic syndrome
复制标题
他克莫司在肾病综合征儿童中的群体药代动力学
DOI：
10.1111/bcp.13605
复制
发表时间：
2018-08-01
影响因子：
3.4
通讯作者：
Zhao, Wei
中科院分区：
文献类型：
--
作者：
Hao, Guo-Xiang;Huang, Xin;Zhao, Wei
肾病综合征（NS）是儿童肾小球疾病最常见的临床表现。目前，他克莫司（TAC）广泛用于NS儿童。然而，肾病综合征儿童的药代动力学数据有限。本研究旨在评估TAC在儿科NS中的群体药代动力学（PPK）并优化给药方案。
Nephrotic syndrome (NS) is the most common clinical manifestation of glomerular disease in children. Currently, tacrolimus (TAC) is widely used in children with NS. However, pharmacokinetic data in children with nephrotic syndrome is limited. This study was intended to evaluate the population pharmacokinetics (PPK) of TAC in paediatric NS and to optimize dosing regimen.