Microglia Don't Treat All Neurons the Same: The Importance of Neuronal Subtype in Microglia-Neuron Interactions in the Developing Hypothalamus.
Microglia Don't Treat All Neurons the Same: The Importance of Neuronal Subtype in Microglia-Neuron Interactions in the Developing Hypothalamus.
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DOI：
10.3389/fncel.2022.867217
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发表时间：
2022
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
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小胶质细胞现在被认为是大脑发育的整体调节器，吞噬整个神经元，并修剪弱或多余的突触，以塑造和完善未成熟的回路。然而，神经元亚型在指导小胶质细胞活动中的重要性直到最近才得到重视。这一视角将描述迄今为止关于这一主题的已知内容，从整个发育中的大脑开始，然后特别关注发育中的下丘脑。有新的证据表明，小胶质细胞亚群对兴奋性和抑制性神经元的处理方式不同，我们最近的工作表明，甚至附近神经元产生的神经肽的类型也很重要。例如，毗邻下丘脑室旁核表达促肾上腺皮质激素释放激素（CRH）的神经元的小胶质细胞吞噬的兴奋性突触比不接触CRH+神经元的下丘脑室旁核边界的小胶质细胞少。潜在的未来方向和技术考虑将在努力催化这一新兴的和令人兴奋的研究领域进行讨论。这项研究的应用有望创造出针对非典型发育大脑中小胶质细胞-神经元相互作用的独特亚型的更具体的治疗方法。
Microglia are now well-known as integral regulators of brain development, phagocytosing whole neurons, and pruning weak or excess synapses in order to sculpt and refine immature circuits. However, the importance of neuronal subtype in guiding microglial activity has not received much attention until recently. This perspective will delineate what is known about this topic so far, starting with the developing brain as a whole and then focusing on the developing hypothalamus in particular. There is emerging evidence that subpopulations of microglia treat excitatory and inhibitory neurons differently, and our recent work has shown that even the type of neuropeptide produced by the nearby neurons is important. For example, microglia abutting corticotropin-releasing hormone (CRH)-expressing neurons in the paraventricular nucleus of the hypothalamus (PVN) engulf fewer excitatory synapses than do microglia on the borders of the PVN that are not contacting CRH+ neurons. Potential future directions and technical considerations will be discussed in an effort to catalyze this emerging and exciting area of research. Applications of this research may hold promise in creating more specific therapies that target unique subtypes of microglia-neuron interactions in the atypically developing brain.
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影响因子：
64.8
作者：
Masuda, Takahiro;Sankowski, Roman;Prinz, Marco
通讯作者：
Prinz, Marco
DOI：
10.1523/jneurosci.1268-12.2013
发表时间：
2013-02-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lenz KM;Nugent BM;Haliyur R;McCarthy MM
通讯作者：
McCarthy MM
影响因子：
3.7
作者：
Goshen, Inbal;Kreisel, Tirzah;Yirmiya, Raz
通讯作者：
Yirmiya, Raz
影响因子：
32.4
作者：
Hammond, Timothy R.;Dufort, Connor;Stevens, Beth
通讯作者：
Stevens, Beth
影响因子：
3.3
作者：
Hayashi, Y.;Tomimatsu, Y.;Nakanishi, H.
通讯作者：
Nakanishi, H.