Assessment of electroencephalographic functional connectivity in term and preterm neonates
Assessment of electroencephalographic functional connectivity in term and preterm neonates
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DOI：
10.1016/j.clinph.2010.08.025
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发表时间：
2011-04-01
影响因子：
4.7
通讯作者：
Pereda, Ernesto
中科院分区：
文献类型：
--
作者：
Gonzalez, Julian J.;Manas, Soledad;Pereda, Ernesto
目的：目的：研究不同的脑电相互依赖指数对新生儿睡眠脑电功能连接的影响，并分析其与孕龄（CA）、胎龄（GA）和（或）实际年龄（CRA）的相关性。方法：记录3组新生儿（早产儿组、早产儿组和正常新生儿组）在活跃睡眠（AS）和安静睡眠（QS）时8个脑区的脑电数据。（PT; GA：33-34周; CA：39-40周）、初足月新生儿（JT; GA：38-39周; CA：39-40周）和足月新生儿（ST; GA：38-39周; CA：44-45周）。用相干函数评价脑电的功能连通性结果：（1）在β频段AS时，ST组颞区的MSC大于PT组;（B）在δ频段QS时，ST组与PT组在额极区和中央区的PLI和IMC均不同，而ST-JT仅在PLI上存在差异。半球内连通性：（a）在β频段AS期间，ST组左额极-中央颞区和右枕-中央颞区的MSC大于PT组;（B）在β频段QS期间，JT组右枕-中央颞区和左枕-中央颞区的IMC和PLI均不同于PT组和ST组。EEG间和内半球功能连接在新生儿睡眠期间的变化与CA和CRA在δ和β bands.Significance：新生儿的大脑发育在生命的第一周可以追溯到EEG功能连接的特点的变化。(C)2010年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To study how functional connectivity of neonate EEG during sleep is assessed by different interdependence indices and to analyze its dependence on conceptional (CA), gestational (GA) and/or chronological age (CRA).Methods: EEG data from eight cortical regions were recorded during active (AS) and quiet sleep (QS) in three groups of seven neonates each: preterm (PT; GA: 33-34 weeks; CA: 39-40 weeks), junior-term (JT; GA: 38-39 weeks; CA: 39-40 weeks) and senior-term neonates (ST; GA: 38-39 weeks; CA: 44-45 weeks). EEG functional connectivity was assessed bymeans of the coherence function (its magnitude (MSC) and its imaginary part (IMC)) and a measure of phase synchronization called phase lag index (PLI).Results: Inter-hemispheric connectivity: (a) during AS in the beta band, the MSC of the ST group was greater than that of the PT group for the temporal region; (b) during QS in the delta band, both PLI and IMC of the ST group were different to those of the PT group for the frontopolar and central regions, whereas ST-JT differences were only found for PLI. Intra-hemispheric connectivity: (a) during AS in the beta band the MSC of the ST group was greater than that of the PT group for the left frontopolar-centrotemporal and right occipital-centrotemporal regions; (b) during QS in the beta band, both IMC and PLI were different for the JT group than for the PT and the ST groups for the right and left occipital-centrotemporal regions.Conclusions: EEG inter-and intra-hemispheric functional connectivity in neonates during sleep changes with the CA and CRA in delta and beta bands.Significance: The neonate's brain development during the first weeks of life can be traced from changes in the characteristics of EEG functional connectivity. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.