Brain derived neurotropic factor in first-episode psychosis
Brain derived neurotropic factor in first-episode psychosis
复制标题
DOI：
10.1016/j.schres.2006.12.026
复制
发表时间：
2007-03-01
影响因子：
4.5
通讯作者：
Mahadik, Sahebarao
中科院分区：
文献类型：
--
作者：
Buckley, Peter F.;Pillai, Anilkumar;Mahadik, Sahebarao
从目前的神经化学、遗传和治疗研究中，人们对脑神经营养因子在精神分裂症中的作用产生了浓厚的兴趣。神经营养因子在神经元发育和分化（即促进树突发生和突触发生）以及协调神经元对应激/有害刺激的反应中发挥关键作用。此外，神经营养素是单能（多巴胺和血清素）、gabaergy和胆碱能系统的调节剂。这些角色集中在精神分裂症发病病理生理学的重要领域。临床研究表明，与正常对照组相比，精神分裂症患者的脑源性神经营养因子（BDNF）和神经生长因子（NFG）减少，以及接受第一代抗精神病药物（FGAs）或第二代抗精神病药物（SGAs）的患者的差异。我们现在报告首发精神病患者的BDNF水平与正常健康对照的比较。与正常对照（N=14; 290.5 +/- 38.81 pg/ml）相比，首发精神病患者血浆BDNF显著降低（N=15; 135 +/- 21.77 pg/ml； P=0.001; f=12.873）。此外，血浆BDNF水平仅与基线阳性症状评分呈显著负相关（N=13 r=0.584， P=0.0362），与任何认知性能测试电池或运动功能测试得分均无显著相关性。精神病发病时的低BDNF水平表明它可能有助于精神分裂症的发病机制和/或可能是可能的早期治疗干预的有用的神经生物学标记。(c) 2007 Elsevier B.V.版权所有
There is much interest, derived from current neurochemical, genetic, and therapeutic research, in the role of brain neurotrophins in schizophrenia. Neurotrophins play key roles in neuronal development and differentiation (i.e., promoting dendritogenesis and synaptogenesis), and in orchestrating the neuronal response to stress/noxious stimuli. Additionally, neurotrophins are modulators across monominergic (dopamine and serotonin), gabaergic and cholinergic systems. These roles focus on important areas of the etiopathophysiology of schizophrenia. Clinical studies show reductions in brain-derived neurotrophic factor (BDNF) and nerve growth factor (NFG) in schizophrenic patients as compared to normal control subjects, as well as differences in patients receiving first-generation antipsychotics (FGAs) or second-generation antipsychotics (SGAs). We now report on BDNF levels in subjects with first-episode psychosis in comparison with normal healthy controls. Compared to normal controls (N=14; 290.5 +/- 38.81 pg/ml), first-episode psychotic patients showed significant reduction (N=15; 135 +/- 21.77 pg/ml; P=0.001; f=12.873) in plasma BDNF. Additionally, plasma BDNF levels showed a significant negative correlation (N=13' r=0.584, P=0.0362) only with positive symptom scores at base line and no significant correlations were found with any of the cognitive performance test battery or motor function test scores. Low BDNF levels at the onset of psychosis suggest that it may contribute to the pathogenesis of schizophrenia and/or perhaps could be a helpful neurobiological marker for possible early treatment intervention. (c) 2007 Elsevier B.V. All rights reserved.