Endothelial Microvascular Dysfunction and Its Relationship with Haptoglobin Levels in Patients with Different Phenotypes of Chronic Heart Failure
Endothelial Microvascular Dysfunction and Its Relationship with Haptoglobin Levels in Patients with Different Phenotypes of Chronic Heart Failure
复制标题
不同表型慢性心力衰竭患者内皮微血管功能障碍及其与结合珠蛋白水平的关系
DOI：
10.20996/1819-6446-2021-10-05
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发表时间：
2021
影响因子：
0.2
通讯作者：
A. Kazadaeva
中科院分区：
文献类型：
--
作者：
V. Podzolkov;N. Dragomiretskaya;I. G. Beliaev;Ju. S. Kucherova;A. Kazadaeva
瞄准探讨不同表型慢性心力衰竭（CHF）患者血清结合珠蛋白水平与微循环（MC）主要指标的关系。对80例NYHA分级为Ⅱ ~ Ⅳ级的慢性心力衰竭患者进行一般临床检查，采用酶联免疫吸附试验测定血清结合珠蛋白水平，并采用激光多普勒血流仪（LDF）评估小腿上1/3内侧表面MC状态。CHF患者包括左心室射血分数保留（HFpEF; n=27）、中等射血分数（HFmrEF; n=25）和射血分数降低（HFrEF; n=28）的患者。HFpEF组的结合珠蛋白中位值为1387.6 [ 747.5; 1946.9] mg/l，HFmrEF组为1583.4 [818.9; 2201.4] mg/l，HFrEF组为968.5 [509.5; 1324.4] mg/l。相关性分析显示，HFmrEF组（r=-0.628，95%置信区间[CI] -0.256;-0.825，p=0.003）和HFrEF组（r=-0.503，95% CI -0.089;-0.803，p=0.02）中触珠蛋白与内皮频率范围（Ae）振幅之间存在统计学显著相关性。结合珠蛋白水平与Kv和σ呈负相关，并根据内皮细胞频率范围的振幅指数得到结合珠蛋白值的计算公式：[结合珠蛋白]=1787-（4053×Ae）。结合珠蛋白的多因子效应在MC调节的中枢和外周机制中实现。血浆中结合珠蛋白的低值应被视为并发症发生的潜在标志物，并用于CHF患者状态的综合评估。结合珠蛋白的诊断和预后意义的评价，特别是在HFmrEF患者，需要进一步的研究。
Aim. To study the relationship between the level of haptoglobin and the main indicators of microcirculation (MC) in patients with different phenotypes of chronic heart failure (CHF).Materials and methods. Patients with different phenotypes of functional class II-IV chronic heart failure according to NYHA (n=80) underwent a general clinical examination, determination of the serum haptoglobin level by enzyme-linked immunosorbent assay, as well as an assessment of the MC state on the medial surface of the upper third of the leg by laser Doppler flowmetry (LDF).Results. Patients with CHF included patients with preserved left ventricular ejection fraction (HFpEF; n=27, intermediate ejection fraction (HFmrEF; n=25) and reduced ejection fraction (HFrEF; n=28). The median value of haptoglobin in the HFpEF group was 1387.6 [ 747.5; 1946.9] mg/l, in the HFmrEF group was 1583.4 [818.9; 2201.4] mg/l, in the HFrEF group was 968.5 [509.5; 1324.4] mg/l. Correlation analysis revealed statistically significant relationships between haptoglobin and the amplitudes of the endothelial frequency range (Ae) in the groups of HFmrEF (r=-0.628, 95% confidence interval [CI] -0.256; -0.825, p=0.003) and HFrEF (r=-0.503, 95% CI -0.089; -0.803, p=0.02). A negative relationship between the haptoglobin level and Kv and σ was revealed, as well as a formula for calculating the value of haptoglobin was obtained, which is predicted on the basis of the amplitude index of the endothelial frequency range: [haptoglobin]=1787-(4053×Ae).Conclusion. The multifactorial effect of haptoglobin is realized in the central and peripheral mechanisms of MC regulation. Low values of haptoglobin in blood plasma should be considered as a potential marker for the development of complications and used in a comprehensive assessment of the state of patients with CHF. Evaluation of the diagnostic and prognostic significance of haptoglobin, especially in patients with HFmrEF, requires further study.
DOI：
10.1016/j.echo.2014.10.003
发表时间：
2015-01-01
影响因子：
6.5
作者：
Lang, Roberto M.;Badano, Luigi P.;Voigt, Jens-Uwe
通讯作者：
Voigt, Jens-Uwe