Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment.
Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment.
复制标题
DOI：
10.1016/j.brainres.2010.11.032
复制
发表时间：
2011-03-22
期刊：
影响因子：
2.9
通讯作者：
McBride SM
中科院分区：
文献类型：
--
作者：
Choi CH;Schoenfeld BP;Bell AJ;Hinchey P;Kollaros M;Gertner MJ;Woo NH;Tranfaglia MR;Bear MF;Zukin RS;McDonald TV;Jongens TA;McBride SM
Fragile X syndrome is the leading single gene cause of intellectual disabilities. Treatment of a Drosophila model of Fragile X syndrome with metabotropic glutamate receptor (mGluR) antagonists or lithium rescues social and cognitive impairments. A hallmark feature of the Fragile X mouse model is enhanced mGluR-dependent long-term depression (LTD) at Schaffer collateral to CA1 pyramidal synapses of the hippocampus. Here we examine the effects of chronic treatment of Fragile X mice in vivo with lithium or a group II mGluR antagonist on mGluR-LTD at CA1 synapses. We find that long term lithium treatment initiated during development (5–6 weeks of age) and continued throughout the lifetime of the Fragile X mice until 9–11 months of age restores normal mGluR-LTD. Additionally, chronic short term treatment beginning in adult Fragile X mice (8 weeks of age) with either lithium or an mGluR antagonist is also able to restore normal mGluR-LTD. Translating the findings of successful pharmacologic intervention from the Drosophila model into the mouse model of Fragile X syndrome is an important advance, in that this identifies and validates these targets as potential therapeutic interventions for the treatment of individuals afflicted with Fragile X syndrome.
登录
查看更多内容
影响因子：
2.9
作者：
Bordi, F;Reggiani, A;Conquet, F
通讯作者：
Conquet, F
影响因子：
16.2
作者：
Ehninger, Dan;Li, Weidong;Fox, Kevin;Stryker, Michael P.;Silva, Alcino J.
通讯作者：
Silva, Alcino J.
影响因子：
16.2
作者：
Dockendorff, TC;Su, HS;Jongens, TA
通讯作者：
Jongens, TA
DOI：
10.1073/pnas.220413597
发表时间：
2000-10-24
影响因子：
11.1
作者：
Fang, XJ;Yu, SX;Mills, GB
通讯作者：
Mills, GB
影响因子：
3.6
作者：
BERRYKRAVIS, E;HICAR, M;CIURLIONIS, R
通讯作者：
CIURLIONIS, R