A global genomic transcriptional code associated with CNS-expressed genes
A global genomic transcriptional code associated with CNS-expressed genes
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DOI：
10.1016/j.yexcr.2006.06.017
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发表时间：
2006-10-01
影响因子：
3.7
通讯作者：
Ericson, Johan
中科院分区：
文献类型：
--
作者：
Bailey, Peter J.;Klos, Joanna M.;Ericson, Johan
高度保守的非编码DNA区域（HCNR）在脊椎动物基因组中普遍存在，但其功能作用尚不清楚。在这里，我们提供的证据表明，大部分HCNRs富集于Sox， POU和同源域转录因子的结合位点，并且这些HCNRs可以作为神经干细胞中活跃的顺式调控区域。引人注目的是，这些HCNRs与发育中的中枢神经系统中表达的数百个基因相关联，它们可能对其基因组位置两侧的多个基因发挥全位点调控作用。此外，这些数据暗示了大量cns表达基因的统一转录逻辑，其中Sox和POU蛋白作为转录的通用启动子，而Homeodomain蛋白通过主动抑制来控制基因的空间表达。(c) 2006爱思唯尔公司版权所有。
Highly conserved non-coding DNA regions (HCNR) occur frequently in vertebrate genomes, but their functional roles remain unclear. Here, we provide evidence that a large portion of HCNRs are enriched for binding sites for Sox, POU and Homeodomain transcription factors, and such HCNRs can act as cis-regulatory regions active in neural stem cells. Strikingly, these HCNRs are linked to several hundreds of genes expressed in the developing CNS and they may exert locus-wide regulatory effects on multiple genes flanking their genomic location. Moreover, these data imply a unifying transcriptional logic for a large set of CNS-expressed genes in which Sox and POU proteins act as generic promoters of transcription while Homeodomain proteins control the spatial expression of genes through active repression. (c) 2006 Elsevier Inc. All rights reserved.