Antifungal Abietane-Type Diterpenes from the Cones of Taxodium distichum Rich
Antifungal Abietane-Type Diterpenes from the Cones of Taxodium distichum Rich
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DOI：
10.1007/s10886-010-9875-2
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发表时间：
2010-12-01
影响因子：
2.3
通讯作者：
Takahashi, Koetsu
中科院分区：
文献类型：
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作者：
Kusumoto, Norihisa;Ashitani, Tatsuya;Takahashi, Koetsu
研究了二枝杉球果的化学成分和十二种二萜类化合物对两种木材腐烂真菌——Trametes versicolor（白腐病）和Fomitopsis palustris（褐腐病）的抗真菌活性。对主要提取部分 n-C(6)H(14) 提取物的化学成分进行了评估，并鉴定了其抗真菌特性。从 n-C(6)H(14) 提取物中分离出 12 种二萜类化合物，包括 10 种松香烷型成分：6,7-脱氢铁红醇 (1)、铁红醇 (2)、6,7-脱氢鹿角酮 (3)、山达海松酸 (4)、紫杉二酮 (5)、紫杉烷 (6)、紫杉酮 (7)、杉酚 (8)、xanthoperol (9)、沙维诺龙 (10)、5,6-脱氢杉醇 (11) 和 14-deoxycoleon U (12)。化合物 5 和 12 对两种木材腐烂真菌均具有高度活性。特别是，这些化合物针对沼泽埃希氏菌的活性非常有效。结果表明，松香烷型结构上羟基的位置和数量可能与对云芝和沼泽沼泽菌的抗真菌活性有关。
The chemical composition of Taxodium distichum cones and the antifungal activities of twelve diterpenoids against two wood decay fungi, Trametes versicolor (white-rot) and Fomitopsis palustris (brown-rot) were examined. The chemical composition of the major extractive fraction, the n-C(6)H(14) extract, was evaluated and its antifungal properties were identified. Twelve diterpenoids including ten abietane-type components were isolated from the n-C(6)H(14) extract: 6,7-dehydroferruginol (1), ferruginol (2), 6,7-dehydroroyleanone (3), sandaracopimaric acid (4), taxodione (5), taxodal (6), taxodone (7), sugiol (8), xanthoperol (9), salvinolone (10), 5,6-dehydrosugiol (11), and 14-deoxycoleon U (12). Compounds 5 and 12 were highly active against both wood-decay fungi. In particular, the activities of these compounds against E palustris were potent. The results suggest that the position and the number of hydroxyl groups on abietane-type structures may be related to antifungal activities against T versicolor and E palustris.