Cerebellar gray matter volume correlates with duration of cocaine use in cocaine-dependent subjects
Cerebellar gray matter volume correlates with duration of cocaine use in cocaine-dependent subjects
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DOI：
10.1038/sj.npp.1301346
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发表时间：
2007-10-01
影响因子：
7.6
通讯作者：
Renshaw, Perry F.
中科院分区：
文献类型：
--
作者：
Sim, Minyoung E.;Lyoo, In Kyoon;Renshaw, Perry F.
本研究使用优化的基于体素的形态测量法（VBM）探索可卡因依赖者和健康对照受试者之间的灰色和白色物质体积的差异。对40名可卡因依赖受试者（41.4 ± 6.9岁，27名男性）和41名年龄和性别匹配的健康对照受试者（38名男性）进行了脑磁共振成像（MRI）和神经心理功能测试。+/-78.8岁，26名男性）。最佳标准化的全脑MR图像进行分割，调制，平滑，并与统计参数映射组之间进行比较。可卡因依赖组双侧运动前区皮质灰质体积较低（Brodmann区（BA）6，8; 16.6%），右眶额皮质（BA 10，15.1%），双侧颞叶皮质（BA 20，38; 15.9%），左侧丘脑（12.6%），及双侧小脑（13.4%）以及右下小脑白色物质体积（10.0%）相对于对照组，多重比较的校正p < 0.05。可卡因使用时间与右侧和左侧小脑灰质体积呈负相关（r =-0.37，r =-0.39）。在可卡因依赖的受试者中，小脑半球下部灰质和白色物质体积与执行功能缺陷和运动表现下降相关。这项研究报告说，可卡因依赖的受试者有较低的灰质体积在小脑半球，以及在额叶，颞叶皮层和丘脑。这些发现首次表明小脑可能容易受到可卡因相关脑容量变化的影响，并且小脑缺陷可能导致在可卡因依赖受试者中经常观察到的神经心理缺陷和运动功能障碍。
This study was conducted to explore differences in gray and white matter volume between cocaine-dependent and healthy comparison subjects using optimized voxel-based morphometry (VBM). Brain magnetic resonance imaging (MRI) and neuropsychological function tests were performed for 40 cocaine-dependent subjects (41.4 +/-6.9 years, 27 men) and 41 healthy age- and sex-matched comparison subjects (38. +/-78.8 years, 26 men). Optimally normalized whole brain MR images were segmented, modulated, smoothed, and compared between groups with statistical parametric mapping. The cocaine-dependent group had lower gray matter volumes in bilateral premotor cortex (Brodmann area (BA) 6, 8; 16.6%), right orbitofrontal cortex (BA 10, 15.1%), bilateral temporal cortex (BA 20, 38; 15.9%), left thalamus (12.6%), and bilateral cerebellum (13.4%) as well as lower right cerebellar white matter volume (10.0%) relative to the comparison group at a corrected p < 0.05 for multiple comparisons. Duration of cocaine use negatively correlated with right and left cerebellar gray matter volumes (r = -0.37, r = -0.39, respectively). In cocaine-dependent subjects, lower cerebellar hemispheric gray and white matter volumes were correlated with deficits in executive function and decreased motor performance. This study reports that cocaine-dependent subjects have lower gray matter volumes in cerebellar hemispheres as well as in frontal, temporal cortex, and thalamus. These findings are the first to suggest that the cerebellum may be vulnerable to cocaine-associated brain volume changes, and that cerebellar deficits may contribute to neuropsychological deficits and motor dysfunction frequently observed in cocaine-dependent subjects.