Microwave ablation with a single small-gauge triaxial antenna: In vivo porcine liver model
Microwave ablation with a single small-gauge triaxial antenna: In vivo porcine liver model
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DOI：
10.1148/radiol.2422051411
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发表时间：
2007-02-01
期刊：
影响因子：
19.7
通讯作者：
Lee, Fred T., Jr.
中科院分区：
文献类型：
--
作者：
Brace, Christopher L.;Laeseke, Paul F.;Lee, Fred T., Jr.
用途：为了评估在体内猪肝model.Materials和方法的微波消融17号三轴天线的性能：这项研究是由机构动物护理和使用委员会批准。使用了13头雌性家猪（平均体重45 kg）。使用原型微波消融系统和三轴天线进行消融，使用68 W的恒定连续波功率，持续2（n = 6）、3（n = 6）、4（n = 6）、5（n = 6）、6（n = 6）、7（n = 13）、10（n = 7）和12（n = 8）分钟。消融后对动物实施安乐死，取出肝脏，对消融区进行切片并测量尺寸和圆度。一个混合的线性模型与动物建模为随机效应被用来测试消融区指标的显着差异之间的时间groups;事后检验被用来检测时间groups.Results之间的显着差异：平均消融区直径范围从2.05 cm +/- 0.23（标准差）在2分钟到2.59 cm +/- 0.53在12分钟。在5-12分钟时间组，观察到40个消融区中有13个（32%）的平均最大直径大于3.0 cm。各组间消融区直径无显著差异（P > 0.05），但直径随时间增加。所有消融区的平均等周比（圆度的测量）为0.88 +/- 0.02，这表明最小的散热vessels.Conclusion：三轴微波消融系统能够在几分钟内创建相对较大的圆形消融区，局部血流的影响最小。(c)RSNA，2007年。
Purpose: To evaluate the performance of a 17-gauge triaxial antenna at microwave ablation in an in vivo porcine liver model.Materials and Methods: This study was approved by the institutional animal care and use committee. Thirteen female domestic pigs (mean weight, 45 kg) were used. Ablations were performed with a prototype microwave ablation system and triaxial antenna by using a constant, continuous-wave power of 68 W for 2 (n = 6), 3 (n = 6), 4 (n = 6), 5 (n = 6), 6 (n = 6), 7 (n = 13), 10 (n = 7), and 12 (n = 8) minutes. Animals were euthanized after ablation, livers were removed, and ablation zones were sliced and measured for size and roundness. A mixed linear model with animals modeled as random effects was used to test for significant differences in ablation zone metrics among time groups; post hoc tests were used to detect significant differences between time groups.Results: Mean ablation zone diameters ranged from 2.05 cm +/- 0.23 (standard deviation) at 2 minutes to 2.59 cm +/- 0.53 at 12 minutes. Thirteen (32%) of 40 ablation zones with mean maximum diameters greater than 3.0 cm were observed at the 5-12-minute time groups. No significant differences in ablation zone diameter were observed among all groups (P >.05), but a trend of increasing diameter with time was noted. Mean isoperimetric ratio (a measure of roundness) for all ablation zones was 0.88 +/- 0.02, which indicates minimal heat sinking near vessels.Conclusion: The triaxial microwave ablation system is capable of creating relatively large, circular zones of ablation in minutes with minimal effects from local blood flow. (c) RSNA, 2007.