Subtle BBB alterations in brain edema associated with acute liver failure.
Subtle BBB alterations in brain edema associated with acute liver failure.
复制标题
与急性肝功能衰竭相关的脑水肿中 BBB 的细微变化。
DOI：
10.1016/j.neuint.2009.07.013
复制
发表时间：
2010
影响因子：
4.2
通讯作者：
Nguyen,JustinH
中科院分区：
文献类型：
--
作者：
Nguyen,JustinH
急性肝衰竭（ALF）中脑水肿的血管源性机制仍知之甚少。最近的研究表明，基质金属蛋白酶 9 (MMP-9) 有助于实验性 ALF 中脑水肿的发生（J Hepatol 44:1105, 2006）。重要的是，用特异性单克隆抗体和/或合成抑制剂阻断 MMP-9，可以减轻水肿。具体来说，超结构评估表明血脑屏障及其紧密连接完整。这些结果表明 BBB 的细微变化可能与 ALF 相关的脑水肿有关。
Vasogenic mechanism of brain edema in acute liver failure (ALF) remains poorly understood. Recent work demonstrates that matrix metalloproteinase-9 (MMP-9) contributes to the development of brain edema in experimental ALF (J Hepatol 44:1105, 2006). Importantly, MMP-9 blockage with specific monoclonal antibodies and/or synthetic inhibitor, the edema is attenuated. Specifically, utrastructural evaluations demonstrate intact blood-brain barrier and its tight junction. These results suggest that subtle alterations in BBB are likely to involve in the brain edema associated with ALF.