Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma.
Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma.
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Trk 酪氨酸激酶受体的表达是人胰腺导管腺癌细胞增殖和神经周围侵袭的生物标志物。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
Kohji Miyazaki
中科院分区：
文献类型：
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作者：
Y. Sakamoto;Y. Kitajima;G. Edakuni;E. Sasatomi;M. Mori;Kenji Kitahara;Kohji Miyazaki
胰腺导管腺癌是一种常见的严重恶性肿瘤，预后差。神经周围侵犯延伸到胰腺外神经丛，这是治疗中的一个重要问题。我们对28例手术切除的PDAC标本进行了神经营养因子（NGF、BDNF、NT-3）及其相关受体Trk酪氨酸激酶受体家族（TrkA、B、C）和p75 NGFR的免疫组织化学分析。几个临床病理因素和Trk受体之间的比较研究揭示了TrkA的表达增加和癌症增殖之间的显着相关性，以及TrkC和癌症浸润，包括静脉和神经周围浸润。本研究结果揭示了PDAC进展中的一种新机制，该机制通过NTs-Trk相互作用介导。
Pancreatic ductal adenocarcinoma (PDAC) is a widely known severe malignancy with a poor prognosis. Perineural invasion extending to the extra-pancreatic nerve plexus, a significant concern in the treatment is frequently present in this cancer. We analyzed immunohistochemical expression of neurotrophins (NGF, BDNF, NT-3) and the cognate receptors, Trk tyrosine kinase receptor family (TrkA, B, C) and p75NGFR in 28 surgically resected PDAC specimens. A comparative study between several clinicopathologic factors and Trk receptors revealed a significant correlation between increased expression of TrkA and cancer proliferation, as well as TrkC and cancer invasion, including venous and perineural invasion. The present findings revealed a novel mechanism in PDAC progression that is mediated via a NTs-Trk interaction.