OVERALL INTERLEUKIN-6 PRODUCTION EXCEEDS 7 MG/DAY IN MULTIPLE-MYELOMA COMPLICATED BY SEPSIS
OVERALL INTERLEUKIN-6 PRODUCTION EXCEEDS 7 MG/DAY IN MULTIPLE-MYELOMA COMPLICATED BY SEPSIS
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DOI：
10.1016/s1043-4666(05)80007-9
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发表时间：
1993-11-01
期刊：
影响因子：
3.8
通讯作者：
KLEIN, B
中科院分区：
文献类型：
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作者：
LU, ZY;BRAILLY, H;KLEIN, B
我们以前报道过，在多发性骨髓瘤（MM）患者中注射抗IL-6单克隆抗体（mAb）可诱导大量IL-6以IL-6/抗IL-6单体复合物的形式循环。这使得有可能估计体内患者的总体每日IL-6产生，这在之前的动物或人类中还没有实现。在这项研究中，估计MM患者在抗IL-6 mAb治疗期间发生大肠杆菌败血症。在前12天期间，总体IL-6产量估计为1.5至2.0 μg/天。第13天，血清IL-6浓度以IL-6/抗IL-6复合物的形式增加1000倍，为1.7× 106 pg/ml，与E.大肠败血症总体IL-6产生估计大于7 mg/天，即比脓毒症之前高3500倍。脓毒症后20天，单体免疫复合物形式的血清IL-6水平保持非常高，表明持续存在非常高的总体IL-6产生（比脓毒症前产生高100至3500倍）。这项研究表明，在脓毒症期间和之后，该患者产生IL-6的潜力相当大且持久。
We previously reported that injection of anti-IL-6 monoclonal antibody (mAb) in a patient with multiple myeloma (MM) induced the circulation of high amounts of IL-6 in the form of IL-6/anti-IL-6 monomeric complexes. This made it possible to estimate overall daily IL-6 production in patients in vivo, which had not been achieved in animals or humans before. In this study, estimations are given for a patient with MM who developedEscherichia colisepsis during anti-IL-6 mAb. During the first 12 days, the overall IL-6 production was estimated at 1.5 to 2.0 μg/day. On day 13, serum IL-6 concentration, in the form of IL-6/anti-IL-6 complexes, increased 1000-fold and was 1.7×106pg/ml, in relation with the development ofE. colisepsis. Overall IL-6 production was estimated to be greater than 7 mg/day, i.e. 3500 times higher than before sepsis. Serum IL-6 levels in the form of monomeric immune complexes remained very high for 20 days after sepsis indicating the persistence of very high overall IL-6 production (100 to 3500-fold greater than pre-sepsis production). This study demonstrates a considerable and persistent potential for IL-6 production in this patient during and after sepsis.