The Utility of Fisher's Geometric Model in Evolutionary Genetics.
The Utility of Fisher's Geometric Model in Evolutionary Genetics.
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DOI：
10.1146/annurev-ecolsys-120213-091846
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发表时间：
2014-11-01
期刊：
影响因子：
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通讯作者：
Tenaillon O
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文献类型：
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作者：
Tenaillon O
关于适应的基因组基础的数据的积累重新引发了人们对适应理论模型的兴趣。在这些模型中，Fisher几何模型(FGM)在过去的二十年里受到了极大的关注。女性生殖器切割是基于一个连续的多维表型景观，但它是为了个体突变效应的新特性而最常用的。尽管表面上很简单，参数有限，但女性生殖器切割整合了一个完整的突变和上位相互作用模型，允许研究有益和有害的突变，以及随后进化人口的命运。在这篇综述中，我介绍了功能梯度材料的不同性质，以及它们从实验进化数据中得到的定性和定量支持。后来我讨论了如何估计模型的不同参数，并概述了一些未来的方向，以连接女性生殖器切割和适应的分子决定因素。
The accumulation of data on the genomic bases of adaptation has triggered renewed interest in theoretical models of adaptation. Among these models, Fisher Geometric Model (FGM) has received a lot of attention over the last two decades. FGM is based on a continuous multidimensional phenotypic landscape, but it is for the emerging properties of individual mutation effects that it is mostly used. Despite an apparent simplicity and a limited number of parameters, FGM integrates a full model of mutation and epistatic interactions that allows the study of both beneficial and deleterious mutations, and subsequently the fate of evolving populations. In this review, I present the different properties of FGM and the qualitative and quantitative support they have received from experimental evolution data. I later discuss how to estimate the different parameters of the model and outline some future directions to connect FGM and the molecular determinants of adaptation.