FERRITIN AND CERULOPLASMIN IN OXIDATIVE DAMAGE - REVIEW AND RECENT FINDINGS
FERRITIN AND CERULOPLASMIN IN OXIDATIVE DAMAGE - REVIEW AND RECENT FINDINGS
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DOI：
10.1139/y93-107
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发表时间：
1993-09-01
影响因子：
2.1
通讯作者：
AUST, SD
中科院分区：
文献类型：
--
作者：
DESILVA, DM;AUST, SD
生物分子如脂质、蛋白质和DNA的氧化与多种毒性和病理学有关。在一个包罗万象的定义中，这些氧化过程被称为“氧化应激”。虽然分子氧与大多数生物分子之间的直接反应是自旋禁止的，但过渡金属如铁和铜可以有效地催化这一反应。铁尤其被证明是生物氧化的有力催化剂。本文就铜蛋白铜蓝蛋白与铁和铜之间的关系作一综述，铜蓝蛋白可能通过催化铁蛋白中铁的氧化而在铁的动态平衡中发挥作用。
The oxidation of biomolecules such as lipid, protein, and DNA is associated with a variety of toxicities and pathologies. In an all-encompassing definition these oxidative processes have been referred to as ''oxidative stress.'' Although the direct reaction between molecular oxygen and most biomolecules is spin forbidden, this reaction can be efficiently catalyzed by transition metals such as iron and copper. Iron especially has been demonstrated to be a potent catalyst of biological oxidations. This review focuses on the relationship between iron and copper with respect to the copper protein ceruloplasmin, which may play a role in iron homeostasis by catalyzing the oxidation of iron as it is placed in ferritin.