Carbamazepine Levels in Breast Milk
Carbamazepine Levels in Breast Milk
复制标题
母乳中卡马西平的含量
DOI：
10.1097/00007691-198409000-00002
复制
发表时间：
1984
影响因子：
2.5
通讯作者：
P. Rausch
中科院分区：
文献类型：
--
作者：
W. Froescher;M. Eichelbaum;M. Niesen;K. Dietrich;P. Rausch
摘要：测定了 19 名癫痫患者的母乳卡马西平 (CBZ) 浓度，其中 13 名患者正在接受 CBZ 单一疗法。这 13 名患者中的 2 名患者接受了 CBZ 单一疗法的两个哺乳期随访。母乳中的 CBZ 浓度为母体 CBZ 血清水平（平均值）的 36.4%。相关系数为0.44；回归线遵循方程 y = 0.12x + 1.63。测定了哺乳期总共 50 个乳汁样品中的 CBZ 浓度（单一疗法加联合疗法的病例）。 CBZ 浓度范围为 1 至 4.8 μg/ml（平均 2.5 μg/ml）。测量了 4 名患者母体血清中游离 CBZ 的浓度。母乳中的 CBZ 与游离 CBZ 水平之间的相关性为 1.6 至 1.8。牛奶中的氨基氮杂环氧化物 (ECBZ) 与血清中测得的 ECBZ 之比为 0.53。一名患者在分娩后观察到持续溢乳。分娩后 3.5 年测定的 CBZ 和 ECBZ 水平在牛奶中高于血清中。对母亲接受 CBZ 单一疗法的母乳喂养和非母乳喂养儿童的观察显示，15 名婴儿中只有 1 名的哺乳不良。
Summary: The carbamazepine (CBZ) concentration of breast milk was determined in 19 epileptic patients of whom 13 were receiving CBZ monotherapy. Two lactation periods under CBZ monotherapy were followed in 2 of these 13 patients. The CBZ concentration of the breast milk was 36.4% of the maternal CBZ serum level (mean value). The correlation coefficient was 0.44; the regression line follows the equation y = 0.12x + 1.63. The CBZ concentration was measured in a total of 50 milk samples during the lactation period (cases of monotherapy plus combination therapy). The CBZ concentration ranged from 1 to 4.8 μg/ml (mean 2.5 μg/ml). The free CBZ concentration in the maternal serum was measured in four patients. The correlation between CBZ in the breast milk and free CBZ levels was 1.6 to 1.8. The ratio of carbam-azepine-epoxide (ECBZ) in the milk to ECBZ determined in serum was 0.53. Continuing galactorrhea after delivery was observed in one patient. The CBZ and ECBZ levels determined 3.5 years after delivery were higher in the milk than in the serum. The observations of breast-fed and non-breast-fed children whose mothers were on CBZ monotherapy disclosed poor suckling in only 1 of 15 infants.