A direct catalytic asymmetric mannich-type reaction to syn-amino alcohols.
A direct catalytic asymmetric mannich-type reaction to syn-amino alcohols.
复制标题
DOI：
10.1021/ja028782e
复制
发表时间：
2003-01
影响因子：
15
通讯作者：
B. Trost;Lamont R. Terrell
中科院分区：
文献类型：
--
作者：
B. Trost;Lamont R. Terrell
曼尼希反应是构造含氮化合物的最广泛应用的化学转化之一。随着药物和天然产物中氮的增加，高度不对称的曼尼希反应变体是可取的。在这篇通讯中，我们报道了我们的双核锌催化剂在一个高度不对称的曼尼奇型反应中生成合成1,2-氨基醇的应用。
The Mannich reaction is one of the most widely utilized chemical transformations for the construction of nitrogen-containing compounds. With the increasing occurrence of nitrogen in drugs and natural products, highly asymmetric variants of the Mannich reaction are desirable. In this communication, we report the application of our dinuclear zinc catalyst to a highly asymmetric Mannich-type reaction to generate syn 1,2-amino alcohols.