In Vitro Fertilization is Associated with an Increased Risk for Preeclampsia
In Vitro Fertilization is Associated with an Increased Risk for Preeclampsia
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DOI：
10.1080/10641950802001859
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发表时间：
2009-01-01
影响因子：
1.5
通讯作者：
Walker, Mark C.
中科院分区：
文献类型：
--
作者：
Chen, Xi-Kuan;Wen, Shi Wu;Walker, Mark C.
目的：探讨宫腔内人工授精、体外受精（IVF）及促排卵治疗与子痫前期的关系。研究方法：我们基于2005年加拿大安大略Niday围产期数据库，对通过辅助生殖技术受孕的妊娠进行了一项基于人群的回顾性队列研究（1357例暴露受试者，5190例对照）。所有辅助生殖技术妊娠均被确定为暴露组。四个对照组随机匹配每个暴露受试者的母亲年龄，产次，多个，和分娩医院的水平和居住区。通过条件Logistic回归模型与相应的对照组比较，评估与宫腔内人工授精、IVF和促排卵相关的先兆子痫风险。结果如下：随着孕妇年龄、孕期吸烟和产前检查开始时间的调整，体外受精与先兆子痫的风险增加相关（OR = 1.78，95%CI：1.05，3.06），而宫腔内人工授精（OR = 2.44，95% CI：0.74，8.06）和促排卵（OR = 1.34，95% CI：0.31，5.75）与先兆子痫的风险无关。结论：IVF妊娠中先兆子痫的发生率较高，但在宫腔内人工授精和促排卵中未发现显著相关性。
Objective: To assess the association of intrauterine insemination, in vitro fertilization (IVF) and ovulation induction with the risk of preeclampsia. Methods: We conducted a population based retrospective cohort study of pregnancies conceived by assisted reproductive technology (1357 exposure subjects, 5190 controls) based on 2005 Niday Perinatal Database for Ontario, Canada. All pregnancies conceived by assisted reproductive technology were identified as exposure group. Four controls were randomly matched for each exposure subject by maternal age, parity, plurality, and delivery hospital level and residence area. The risks for preeclampsia associated with intrauterine insemination, IVF, and ovulation induction were evaluated through conditional logistic regression models compared with their corresponding controls. Results: With adjustment of maternal age, smoking during pregnancy and initiating time of prenatal care, in vitro fertilization was associated with an increased risk for preeclampsia (OR = 1.78, 95% CI: 1.05, 3.06), whereas intrauterine insemination (OR = 2.44, 95% CI: 0.74, 8.06) and ovulation induction (OR = 1.34, 95% CI: 0.31, 5.75) was not associated with the risk for preeclampsia. Conclusion: There was a higher incidence of preeclampsia among pregnancies conceived by IVF, but no significant association was found in intrauterine insemination and ovulation induction.