Molecular Mechanisms of UVA-Induced Melanoma
Molecular Mechanisms of UVA-Induced Melanoma
复制标题
UVA 诱发黑色素瘤的分子机制
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Gongsang Duoji
中科院分区：
文献类型：
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作者：
Xiao Pudroma;Gongsang Duoji
皮肤黑色素瘤是一种致命的皮肤癌，由黑色素细胞的恶性转化引起。长波紫外线辐射（315-400 nm）能够损伤DNA，引起突变，并诱发黑色素瘤。然而，UVA诱导的皮肤黑色素瘤的确切机制仍然是一个有争议的问题。在这篇综述中，我们简要介绍了UVA在黑色素瘤发生中的光生物学中最重要的元素。
Cutaneous melanoma is a deadly skin cancer, resulting from malignant transformation of melanocytes..Long-wave ultraviolet radiation (315–400 nm) is able to damage DNA, cause mutations, and induce melanoma..However, the exact mechanisms of UVA-induced cutaneous melanoma remain a matter of debate. In this review,.we give a brief characterization of the most important elements in the photobiology of UVA in melanomagenesis.