Cathelicidins, essential gene-encoded mammalian antibiotics
Cathelicidins, essential gene-encoded mammalian antibiotics
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DOI：
10.1007/s00109-002-0350-6
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发表时间：
2002-06
期刊：
影响因子：
--
通讯作者：
M. Zaiou;R. Gallo
中科院分区：
文献类型：
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作者：
M. Zaiou;R. Gallo
Cathelicidins是一类基因编码的抗生素，仅在哺乳动物中发现。体外和体内研究表明，它们是哺乳动物先天免疫的效应分子，可以提供针对一系列微生物的第一道防线。这类抗菌肽的一些成员的其他功能，包括趋化活性，有丝分裂，和血管生成。因此，这些肽被认为是多功能效应分子。本文综述了抗菌肽的研究进展及其功能特性。目前在这一领域的工作表明，了解哺乳动物先天免疫系统的这一组成部分和相关的天然抗生素肽提供了一个机会，用于开发新的治疗药物，以对抗持续存在的抗菌素耐药性问题。
Cathelicidins are a class of gene-encoded antibiotics found exclusively in mammals. In vitro and in vivo studies indicate they are effector molecules of mammalian innate immunity that can provide a first line of defense against an array of micro-organisms. Additional functions are described for some members of this class of antimicrobial peptides including chemotactic activity, mitogenesis, and angiogenesis. Therefore these peptides are considered to be multifunctional effector molecules. This review discusses recent progress in cathelicidin research and the functional properties of cathelicidins. Current work in this field suggests that understanding this component of the mammalian innate immune system and related natural antibiotic peptides offer an opportunity for the development of novel therapeutic agents with which to battle the continued problem of antimicrobial resistance.