Energy metabolism of cells in the macula flava of the newborn vocal fold from the aspect of mitochondrial microstructure
Energy metabolism of cells in the macula flava of the newborn vocal fold from the aspect of mitochondrial microstructure
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DOI：
10.1017/s0022215121001614
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发表时间：
2021-09-01
影响因子：
1.7
通讯作者：
Umeno，H.
中科院分区：
文献类型：
--
作者：
Sato，K.;Chitose，S.;Umeno，H.
黄斑声带中的细胞可能是组织干细胞。方法应用透射电镜观察5例正常新生儿声带细胞线粒体的超微结构，观察其能量代谢过程。然而，这些膜是模糊的。各层嵴稀疏。嵴间隙被线粒体基质占据。部分线粒体与脂滴和粗面内质网融合，线粒体外膜和内膜嵌顿消失。结论新生儿黄斑细胞线粒体的特征显示其代谢活性和氧化磷酸化活性较低。新生黄斑细胞的代谢有利于维持细胞的干性和未分化。
ObjectiveCells in the vocal fold of maculae flavae are likely to be tissue stem cells. Energy metabolism of the cells in newborn maculae flavae was investigated from the aspect of mitochondrial microstructure.MethodFive normal newborn vocal folds were investigated under transmission electron microscopy.ResultsMitochondria consisted of a double membrane bounded body containing matrices and a system of cristae. However, these membranes were ambiguous. In each mitochondrion, the lamellar cristae were sparse. Intercristal space was occupied by a mitochondrial matrix. Some mitochondria had fused to lipid droplets and rough endoplasmic reticulum, and both the mitochondrial outer and inner membranes had incarcerated and disappeared.ConclusionThe features of the mitochondria of the cells in the newborn maculae flavae showed that their metabolic activity and oxidative phosphorylation were low. The metabolism of the cells in the newborn maculae flavae seems to be favourable to maintain the stemness and undifferentiation of the cells.