Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.
Dopamine/adenosine interactions related to locomotion and tremor in animal models: possible relevance to parkinsonism.
复制标题
动物模型中与运动和震颤相关的多巴胺/腺苷相互作用：可能与帕金森症相关。
DOI：
10.1016/j.parkreldis.2008.04.017
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发表时间：
2008
影响因子：
4.1
通讯作者：
Correa,Mercè
中科院分区：
文献类型：
--
作者：
Salamone,JohnD;Ishiwari,Keita;Betz,AdrienneJ;Farrar,AndrewM;Mingote,SusanaM;Font,Laura;Hockemeyer,Jörg;Müller,ChristaE;Correa,Mercè
Adenosine A2Aantagonists can exert antiparkinsonian effects in animal models. Recent experiments studied the ability of MSX-3 (an adenosine A2Aantagonist) to reverse the locomotor suppression and tremor produced by dopamine antagonists in rats. MSX-3 reversed haloperidol-induced suppression of locomotion, and reduced the tremulous jaw movements induced by haloperidol, pimozide, and reserpine. Infusions of MSX-3 into the nucleus accumbens core increased locomotion in haloperidol-treated rats, but there were no effects of infusions into the accumbens shell or ventrolateral neostriatum. In contrast, MSX-3 injected into the ventrolateral neostriatum reduced pimozide-induced tremulous jaw movements. Dopamine/adenosine interactions in different striatal subregions are involved in distinct aspects of motor function.
