Re-irradiation using proton beam therapy combined with weekly intra-arterial chemotherapy for recurrent oral cancer.
Re-irradiation using proton beam therapy combined with weekly intra-arterial chemotherapy for recurrent oral cancer.
复制标题
使用质子束治疗结合每周动脉内化疗治疗复发性口腔癌进行再照射。
DOI：
10.1111/ajco.12502
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Tohnai I.
中科院分区：
文献类型：
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作者：
Hayashi Y;Nakamura T;Mitsudo K;Kimura K;Yamaguchi H;Ono T;Azami Y;Takayama K;Hirose K;Yabuuchi T;Suzuki M;Hatayama Y;Kikuchi Y;Wada H;Fuwa N;Hareyama M;Tohnai I.
AimThe purpose of this study was to clarify the efficacy and toxicities of re-irradiation using proton beam therapy combined with weekly intra-arterial chemotherapy for recurrent oral cancer.MethodsBetween October 2009 and July 2014，34 patients who have recurrent oral cancer were treated by proton beam therapy combined with intra-arterial infusion chemotherapy at Southern Tohoku Proton Therapy Center，Japan.ResultsFor all patients，中位随访时间为25个月（范围：3-77个月）。治疗后，22例患者（65%）在原发肿瘤部位获得完全缓解，12例患者（35%）获得部分缓解。1年和2年总生存率（OS）分别为62%和42%。1年和2年LC率分别为77%和60%。在治疗和随访期间没有观察到治疗相关的死亡。结论与其他治疗方式相比，使用质子束治疗结合每周动脉内化疗的再照射可改善OS和局部控制率，并可能成为复发性口腔癌患者的新治疗方式。
AimThe purpose of this study was to clarify the efficacy and toxicities of re‐irradiation using proton beam therapy combined with weekly intra‐arterial chemotherapy for recurrent oral cancer.MethodsBetween October 2009 and July 2014, 34 patients who had recurrent oral cancer were treated by proton beam therapy combined with intra‐arterial infusion chemotherapy at the Southern Tohoku Proton Therapy Center, Japan.ResultsFor all patients, the median follow‐up was 25 months (range, 3–77 months). After treatment, 22 patients (65%) achieved a complete response, and 12 patients (35%) achieved a partial response at the primary tumor site. One‐year and 2‐year overall survival (OS) rates were 62% and 42%, respectively. One‐year and 2‐year LC rates were 77% and 60%, respectively. No treatment‐related deaths were observed during the treatment and follow‐up periods.ConclusionRe‐irradiation using proton beam therapy combined with weekly intra‐arterial chemotherapy improved OS and local control rates compared with other treatment modalities and could become a new treatment modality for patients with recurrent oral cancer.