An unprecedented base-promoted domino reaction of methyleneindolinones and N-tosyloxycarbamates for the construction of bispirooxindoles and spiroaziridine oxindoles.
An unprecedented base-promoted domino reaction of methyleneindolinones and N-tosyloxycarbamates for the construction of bispirooxindoles and spiroaziridine oxindoles.
复制标题
DOI：
10.1039/c5cc03793j
复制
发表时间：
2015-06
影响因子：
4.9
通讯作者：
Qilin Wang;Tian Cai;Jing Zhou;Fang Tian;Xiao‐Ying Xu;Li‐Xin Wang
中科院分区：
文献类型：
--
作者：
Qilin Wang;Tian Cai;Jing Zhou;Fang Tian;Xiao‐Ying Xu;Li‐Xin Wang
亚甲基吲哚啉酮和N-甲苯磺酰氧基氨基甲酸酯的有效和前所未有的多米诺反应已经被开发，以优异的产率（高达98%）提供结构复杂和多样的双螺环羟吲哚，并以中等至良好的产率（55-91%）提供螺氮丙啶羟吲哚。此外，该方法还可以高产率地得到不对称的双螺羟吲哚和各种稠合螺环吡咯烷。
An efficient and unprecedented domino reaction of methyleneindolinones and N-tosyloxycarbamates has been developed to afford structurally complex and diverse bispirooxindoles in excellent yields (up to 98%) and spiroaziridine oxindoles in moderate to good yields (55-91%). Moreover, this protocol could also provide the unsymmetrical bispirooxindoles and various fused spirocyclic pyrrolidines in excellent yields.