Reusable electrochemical non-enzymatic glucose sensors based on Au-inlaid nanocages
Reusable electrochemical non-enzymatic glucose sensors based on Au-inlaid nanocages
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DOI：
10.1007/s12274-022-4219-4
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发表时间：
2022-04
期刊：
影响因子：
9.9
通讯作者：
Lu Shen;Zhen Liang;Zhiyu Chen;Can Wu;X. Hu;J. Zhang;Qing Jiang;Yunbing Wang
中科院分区：
文献类型：
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作者：
Lu Shen;Zhen Liang;Zhiyu Chen;Can Wu;X. Hu;J. Zhang;Qing Jiang;Yunbing Wang
许多应用都需要对葡萄糖进行质量检测，但这仍然具有挑战性。商业酶基葡萄糖测试条不能重复使用，并且当前的非酶葡萄糖传感器表现出检测范围窄和葡萄糖氧化动力学缓慢。在此，对普鲁士蓝类似物 (PBA) 纳米立方体的顶点进行受控蚀刻，然后通过 HAuCl4 的原位还原将金纳米粒子 (Au NP) 镶嵌在蚀刻的空腔中。独特的 AuNP-PBA 纳米复合物表现出葡萄糖氧化的低电化学势、高电催化活性和快速的氧化还原电子转移速率。将金镶嵌纳米材料共价固定在细金线上，形成的非酶葡萄糖传感器具有特别宽的线性检测范围（10 µM 至 16 mM）、出色的抗干扰性和快速响应。更重要的是，该传感器可重复使用，即使检测150次后其灵敏度仍能保持良好。这种新概念材料有望以低成本实现高通量葡萄糖检测，这对于糖尿病管理和其他医疗保健应用至关重要。
Mass detection of glucose, which is required in many applications, remains challenging. The commercial enzyme-based glucose test strips cannot be reused, and current non-enzymatic glucose sensors exhibit a narrow range of detection and slow glucose oxidation kinetics. Herein, controlled etching of Prussian blue analogue (PBA) nanocubes at the vertices is conducted and Au nanoparticles (Au NPs) are subsequently inlaid in the etched cavities byin-situreduction of HAuCl4. The unique AuNP-PBA nanocomplexes exhibit low electrochemical potential for glucose oxidation, high electrocatalytic activity, and rapid redox electron transfer rate. Covalent immobilization of the Au-inlaid nanomaterials on a fine Au wire leads to a non-enzymatic glucose sensor with a particularly wide linear detection range (10 µM to 16 mM), excellent anti-interference, and fast response. More importantly, the sensor is reusable, and its sensitivity is well maintained even after 150 times of detection. This new-concept material promises to enable high-throughput glucose detection at a low cost, which is essential in diabetic management and other healthcare applications.