POSSIBLE SITES OF ACTION OF THE RESPIRATORY STIMULANT EFFECT OF DOXAPRAM HYDROCHLORIDE.
POSSIBLE SITES OF ACTION OF THE RESPIRATORY STIMULANT EFFECT OF DOXAPRAM HYDROCHLORIDE.
复制标题
盐酸多沙普仑呼吸刺激作用的可能作用位点。
DOI：
10.1097/00132586-196504000-00016
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发表时间：
1964
期刊：
影响因子：
--
通讯作者：
J. Buckley
中科院分区：
文献类型：
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作者：
H. Kato;J. Buckley
盐酸多沙普仑，1-乙基-4-（2-吗啉代乙基）-3，3-二苯基-2-吡咯烷酮盐酸盐水合物，已被证明是一种有效的呼吸兴奋剂，主要通过直接刺激中枢呼吸中枢发挥作用。已提供的数据表明，该化合物对颈动脉化学感受器产生轻度刺激。该化合物还由于刺激主动脉化学感受器和可能的其他外周化学感受器而产生外周刺激作用。多沙普仑也通过中枢和外周机制产生升压反应。
Doxapram hydrochloride, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate, has been shown to be a potent respiratory stimulant acting mainly through direct stimulation of central respiratory centers. Data have been presented which indicate that the compound produces a mild stimulation of carotid chemoreceptors. The compound also produces a peripheral stimulating effect due to stimulation of the aortic chemoreceptors and possibly other peripheral chemoreceptors. Doxapram also produced pressor responses through both central and peripheral mechanisms.