A biophysical counting mechanism for keeping time.
A biophysical counting mechanism for keeping time.
复制标题
用于计时的生物物理计数机制。
DOI：
10.1007/s00422-021-00915-4
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发表时间：
2022
影响因子：
1.9
通讯作者：
Rinzel,John
中科院分区：
文献类型：
--
作者：
Zemlianova,Klavdia;Bose,Amitabha;Rinzel,John
估计和产生适当时间反应的能力是许多行为的核心，包括说话、跳舞和演奏乐器。用于估计或产生时间间隔的经典框架是起搏器-累加器模型，其中起搏器的脉冲被计数并与存储的表示相比较。然而，这些脉冲如何计数的神经机制仍然是一个悬而未决的问题。噪声和随机性的存在使情况变得更加复杂。我们提出了一个生物物理模型，说明在存在各种形式的随机性的情况下，如何使用非对称连接在一维阵列中的双稳态Wilson-Cowan单元系统来计数起搏器；所有单元都从中央时钟接收相同的输入脉冲，但在任何时间点只有一个单元处于活动状态。对于来自时钟的每个脉冲，激活单元的位置改变，从而对时钟发出的脉冲总数进行编码。这种神经结构将计数问题映射到空间域，而空间域又将计数转换为时间估计。我们进一步将模型扩展到层次结构，以便能够稳健地实现更高的计数。
The ability to estimate and produce appropriately timed responses is central to many behaviors including speaking, dancing, and playing a musical instrument. A classical framework for estimating or producing a time interval is the pacemaker-accumulator model in which pulses of a pacemaker are counted and compared to a stored representation. However, the neural mechanisms for how these pulses are counted remain an open question. The presence of noise and stochasticity further complicates the picture. We present a biophysical model of how to keep count of a pacemaker in the presence of various forms of stochasticity using a system of bistable Wilson-Cowan units asymmetrically connected in a one-dimensional array; all units receive the same input pulses from a central clock but only one unit is active at any point in time. With each pulse from the clock, the position of the activated unit changes thereby encoding the total number of pulses emitted by the clock. This neural architecture maps the counting problem into the spatial domain, which in turn translates count to a time estimate. We further extend the model to a hierarchical structure to be able to robustly achieve higher counts.