Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Health-Related Quality of Life in Sepsis.
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Health-Related Quality of Life in Sepsis.
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DOI：
10.1097/cce.0000000000000270
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发表时间：
2020-12
影响因子：
--
通讯作者：
Donnino MW
中科院分区：
文献类型：
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作者：
Grossestreuer AV;Moskowitz A;Andersen LW;Holmberg MJ;Konacki V;Berg KM;Chase M;Cocchi MN;Donnino MW
经历败血症的患者通常会产生长期影响，可能会影响健康相关的生活质量。本研究旨在探讨抗坏血酸、皮质类固醇和硫胺素联合治疗与安慰剂相比是否能改善感染性休克患者的健康相关生活质量。抗坏血酸、皮质类固醇和硫胺素在脓毒症随机对照试验（NCT 03389555）中的次要分析。美国13家三级医院。入组抗坏血酸、皮质类固醇和硫胺素治疗败血症的患者在入组后存活90天，并能够通过电话联系。患者被随机分配到胃肠外抗坏血酸（1,500 mg），氢化可的松（50 mg），硫胺素（100 mg），每6小时一次，持续4天或安慰剂。117例患者（59%）存活至90天，并接受了简表36问卷调查;其中72例（62%）完成了简表36（干预组38例[53%]，安慰剂组34例[47%]）。66人（92%）完成了所有调查问题（干预组36人（95%），安慰剂组30人（88%））。干预组和安慰剂组之间的简表36总体评分无显著差异（中位评分分别为：39.4 [四分位距，31.2-45.4] vs 43.2 [37.0-46.7]，p = 0.18）。我们发现两组在其他健康相关的生活质量方面没有统计学显著差异。我们发现，与安慰剂相比，抗坏血酸、皮质类固醇和硫胺素联合治疗的感染性休克患者的健康相关生活质量没有差异。
Patients who experience sepsis often have long-term effects that may impact health-related quality of life. This study aimed to investigate whether the combination of ascorbic acid, corticosteroids, and thiamine compared with placebo improves health-related quality of life in patients with septic shock. Secondary analysis of the Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis randomized controlled trial (NCT03389555). Thirteen tertiary-care hospitals in the United States. Patients who were enrolled in Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis, survived to 90 days post enrollment and were able to be contacted by telephone. Patients were randomly assigned to parenteral ascorbic acid (1,500 mg), hydrocortisone (50 mg), and thiamine (100 mg) every 6 hours for 4 days or placebo. One hundred seventeen patients (59%) survived to 90 days and were administered the Short Form 36 questionnaire; of these, 72 (62%) completed the Short Form 36 (38 [53%] in the intervention group, 34 [47%] in placebo). Sixty-six (92%) completed all survey questions (36 [95%] in the intervention group, 30 [88%] in placebo). There was no significant difference in overall Short Form 36 score between intervention and placebo group (median score: 39.4 [interquartile range, 31.2–45.4] vs 43.2 [37.0–46.7], respectively, p = 0.18). We found no statistically significant difference between the two groups in any of the other health-related quality of life domains used. We found no difference in the health-related quality of life in patients with septic shock treated with a combination of ascorbic acid, corticosteroids, and thiamine compared to placebo.