Antibody response to rubella virus structural proteins in multiple sclerosis.
Antibody response to rubella virus structural proteins in multiple sclerosis.
复制标题
多发性硬化症中风疹病毒结构蛋白的抗体反应。
DOI：
10.1002/ana.410270513
复制
发表时间：
1990
影响因子：
11.2
通讯作者：
Wolinsky,JS
中科院分区：
文献类型：
--
作者：
Nath,A;Wolinsky,JS
The antibody response to the structural proteins of rubella virus was studied in patients with multiple sclerosis (MS). Irrespective of the antibody titer to whole rubella virus, the relative proportion of the IgG response to the surface glycoprotein E1 was diminished, and that to the surface glycoprotein E2 was elevated in MS patients when compared to a matched control population of normal healthy individuals or a group of patients with systemic lupus erythematosus and other collagen vascular diseases. No difference was observed in the response to the core protein of rubella virus on comparing the MS and normal control groups. This divergence in the relative antibody response to the viral surface proteins suggests that the vigorous antibody response to rubella virus reported in MS is not simply an expression of a nonspecific polyvalent B‐cell response.
