Effect of Continuous Versus Delayed Insulin Replacement on Sex Behavior and Neuroendocrine Function in Diabetic Male Rats
Effect of Continuous Versus Delayed Insulin Replacement on Sex Behavior and Neuroendocrine Function in Diabetic Male Rats
复制标题
连续与延迟胰岛素替代对糖尿病雄性大鼠性行为和神经内分泌功能的影响
作者：
R. Steger;S. Kienast
在成年雄性大鼠中测试了胰岛素替代逆转链脲佐菌素诱导的糖尿病（STZD）对神经内分泌和性功能的不良影响的能力。给大鼠注射STZ（50 mg/kg）或赋形剂，然后立即开始胰岛素治疗（连续）或在开始胰岛素替代治疗（延迟）之前保持4周不治疗。在关灯前注射胰岛素5IU/kg，开灯后1h内注射胰岛素2 IU/kg，分别在诱导糖尿病后2、4、5、6 wk检测交配行为。STZ给药后45天，处死大鼠，测定血浆激素水平和下丘脑儿茶酚胺周转率和5-羟色胺含量。STZ-D大鼠表现出显着的缺陷，安装，插入，射精行为，防止连续胰岛素替代。延迟胰岛素补充可逆转勃起和插入行为的缺陷，但不能逆转射精行为。血浆促黄体激素水平不受STZ或胰岛素治疗的影响，但血浆睾酮和催乳素水平均降低糖尿病动物。持续或延迟胰岛素替代使睾酮和催乳素水平正常化。STZ给药后，正中隆起、内侧基底下丘脑、前下丘脑和嗅球的去甲肾上腺素周转率均降低。延迟胰岛素替代恢复去甲肾上腺素营业额在所有的大脑区域，而连续胰岛素替代增强去甲肾上腺素营业额在前下丘脑和嗅球，但只有部分阻断STZ的影响，正中隆起和内侧基底下丘脑。STZ诱导下丘脑内侧基底部和嗅球的多巴胺周转率降低，这些变化不能通过胰岛素替代来预防或逆转。这些结果表明，STZ-D对交配行为和神经内分泌功能的许多但不是所有的不良影响可以通过胰岛素替代来逆转。
The ability of insulin replacement to reverse the adverse effects of streptozocin-induced diabetes (STZD) on neuroendocrine and sexual function was tested in adult male rats. Rats were injected with STZ (50 mg/kg) or vehicle and then either started immediately on insulin (continuous) or allowed to remain untreated for 4 wk before insulin replacement was started (delayed). Replacement consisted of 5 IU/kg of insulin injected just before the lights were turned off and 2 IU/kg of insulin injected within 1 h of the lights being turned on. Copulatory behavior was tested 2, 4, 5, and 6 wk after induction of diabetes. Forty-five days after STZ administration, rats were killed for measurement of plasma hormone levels and hypothalamic catecholamine turnover and serotonin content. The STZ-D rats showed significant deficits in mount, intromission, and ejaculatory behaviors that were prevented by continuous insulin replacement. Delayed insulin replacement reversed the deficits in mount and intromission behaviors but not ejaculatory behavior. Plasma luteinizing hormone levels were unaffected by STZ or insulin treatment, but plasma testosterone and prolactin levels were both reduced in the diabetic animals. Continuous or delayed insulin replacement normalized both testosterone and prolactin levels. Median eminence, medial basal hypothalamus, anterior hypothalamus, and olfactory bulb rates of norepinephrine turnover were all reduced after STZ administration. Delayed insulin replacement restored norepinephrine turnover in all brain regions, whereas continuous insulin replacement enhanced norepinephrine turnover in the anterior hypothalamus and olfactory bulb but only partially blocked the effects of STZ in the median eminence and medial basal hypothalamus. STZ induced decreases in dopamine turnover in the medial basal hypothalamus and olfactory bulb, and these changes could not be prevented or reversed by insulin replacement. These results demonstrate that many but not all of the adverse effects of STZ-D on copulatory behavior and neuroendocrine function can be reversed by insulin replacement.
δ9-四氢大麻酚 (THC) 与控制黄体生成素和催乳素释放的下丘脑神经递质的相互作用。
影响因子：
4.1
作者：
Steger,RW;DePaolo,L;Asch,RH;Silverman,AY
通讯作者：
Silverman,AY
金仓鼠睾丸催乳素和黄体生成素受体的调节。
影响因子：
4.8
作者：
Klemcke,HG;Bartke,A;Borer,KT
通讯作者：
Borer,KT
高催乳素血症对雄性大鼠黄体生成素和卵泡刺激素分泌控制的影响。
影响因子：
3.6
作者：
Smith,MS;Bartke,A
通讯作者：
Bartke,A