Zebrafish and medaka as models for biomedical research of bone diseases
Zebrafish and medaka as models for biomedical research of bone diseases
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DOI：
10.1016/j.ydbio.2019.07.009
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发表时间：
2020-01-15
影响因子：
2.7
通讯作者：
Schulte-Merker, S.
中科院分区：
文献类型：
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作者：
Lleras-Forero, L.;Winkler, C.;Schulte-Merker, S.
近年来，由于使用患者材料的全基因组测序方法，致病突变的鉴定取得了巨大进展。因此，任务从基因鉴定转向假定致病基因的功能分析，最好是在体内环境中，这也允许在整个动物疾病模型中测试候选药物或生物治疗药物。在这篇综述中，我们重点介绍了利用小型实验鱼（特别是斑马鱼和青鳉鱼）在骨疾病领域取得的进展。我们特别强调那些可以使用硬骨鱼模型的人类状况。
The identification of disease-causing mutations has in recent years progressed immensely due to whole genome sequencing approaches using patient material. The task accordingly is shifting from gene identification to functional analysis of putative disease-causing genes, preferably in an in vivo setting which also allows testing of drug candidates or biotherapeutics in whole animal disease models. In this review, we highlight the advances made in the field of bone diseases using small laboratory fish, focusing on zebrafish and medaka. We particularly highlight those human conditions where teleost models are available.